Phase-Separation-Induced Formation of Janus Droplets Based on Aqueous Two-Phase Systems

Hao Yuan; Qingming Ma; Yang Song; Matthew Y. H. Tang; Yau Kei Chan; Ho Cheung Shum

doi:10.1002/macp.201600422

Phase-Separation-Induced Formation of Janus Droplets Based on Aqueous Two-Phase Systems

Hao Yuan
, Qingming Ma
, Yang Song
, Matthew Y. H. Tang
, Yau Kei Chan
, Ho Cheung Shum^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

47 Citations (Scopus)

Abstract

In this study, Janus droplets are fabricated by inducing phase separation of single-phase droplets made up of an aqueous two-phase system (ATPS). The resultant Janus droplets are highly monodisperse in structures and internal morphologies. Due to the affinity partitioning properties of ATPS, encapsulated ingredients can automatically partition into different compartments of the resultant Janus droplets. The use of biocompatible and cytocompatible ATPS also enables the encapsulation of enzymes and cells in the resultant droplets with their activity preserved at a relatively high level. (Figure presented.). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Original language	English
Article number	1600422
Journal	Macromolecular Chemistry and Physics
Volume	218
Issue number	2
DOIs	https://doi.org/10.1002/macp.201600422
Publication status	Published - 1 Jan 2017
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This research was supported by the Early Career Scheme (Grant No. HKU 707712P), the General Research Fund (Grant Nos. HKU 719813E, 17304514, and 17306315), and the Collaborative Research Fund (Grant No. C6004-14G) from the Research Grants Council of Hong Kong; the General Program (Grant No. 21476189/B060201) and the Major Research Plan (Grant No. 91434202) from the National Natural Science Foundation of China; and the Seed Funding Program for Basic Research (Grant Nos. 201511159280 and 201411159038) from the University of Hong Kong. The authors also thank Prof. Al-Ubaidi of the University of Oklahoma for providing the 661W cell line.

Research Keywords

aqueous two-phase system
bioactivity preservation
droplet microfluidics
phase separation

RGC Funding Information

RGC-funded

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10.1002/macp.201600422

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title = "Phase-Separation-Induced Formation of Janus Droplets Based on Aqueous Two-Phase Systems",

abstract = "In this study, Janus droplets are fabricated by inducing phase separation of single-phase droplets made up of an aqueous two-phase system (ATPS). The resultant Janus droplets are highly monodisperse in structures and internal morphologies. Due to the affinity partitioning properties of ATPS, encapsulated ingredients can automatically partition into different compartments of the resultant Janus droplets. The use of biocompatible and cytocompatible ATPS also enables the encapsulation of enzymes and cells in the resultant droplets with their activity preserved at a relatively high level. (Figure presented.). {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

keywords = "aqueous two-phase system, bioactivity preservation, droplet microfluidics, phase separation",

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AU - Yuan, Hao

AU - Ma, Qingming

AU - Song, Yang

AU - Tang, Matthew Y. H.

AU - Chan, Yau Kei

AU - Shum, Ho Cheung

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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N2 - In this study, Janus droplets are fabricated by inducing phase separation of single-phase droplets made up of an aqueous two-phase system (ATPS). The resultant Janus droplets are highly monodisperse in structures and internal morphologies. Due to the affinity partitioning properties of ATPS, encapsulated ingredients can automatically partition into different compartments of the resultant Janus droplets. The use of biocompatible and cytocompatible ATPS also enables the encapsulation of enzymes and cells in the resultant droplets with their activity preserved at a relatively high level. (Figure presented.). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

AB - In this study, Janus droplets are fabricated by inducing phase separation of single-phase droplets made up of an aqueous two-phase system (ATPS). The resultant Janus droplets are highly monodisperse in structures and internal morphologies. Due to the affinity partitioning properties of ATPS, encapsulated ingredients can automatically partition into different compartments of the resultant Janus droplets. The use of biocompatible and cytocompatible ATPS also enables the encapsulation of enzymes and cells in the resultant droplets with their activity preserved at a relatively high level. (Figure presented.). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

KW - aqueous two-phase system

KW - bioactivity preservation

KW - droplet microfluidics

KW - phase separation

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U2 - 10.1002/macp.201600422

DO - 10.1002/macp.201600422

M3 - RGC 21 - Publication in refereed journal

SN - 1022-1352

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JO - Macromolecular Chemistry and Physics

JF - Macromolecular Chemistry and Physics

IS - 2

M1 - 1600422

ER -

Phase-Separation-Induced Formation of Janus Droplets Based on Aqueous Two-Phase Systems

Abstract

Bibliographical note

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Research Keywords

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