Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (without host publication)peer-review

View graph of relations

Author(s)

  • M. Garbin
  • J. Benito
  • H.L.M. Ruel
  • R. Watanabe
  • B.P. Monteiro
  • P. Cagnardi

Detail(s)

Original languageEnglish
Publication statusPublished - 20 May 2022

Conference

TitleAssociation of Veterinary Anaesthetists (AVA) Spring Meeting (2022)
LocationFougaro Art Center
PlaceGreece
CityNafplio
Period18 - 20 May 2022

Abstract

This study describes the pharmacokinetics of bupivacaine following administration via an ultrasound-guided transversus abdominis plane (TAP) block in cats undergoing ovariohysterectomy.
Twelve healthy adult cats (3.7 ± 0.7 kg) were included in a randomized, prospective, blinded clinical trial. Anaesthetic protocol included acepromazine-buprenorphine-propofol-isoflurane-meloxicam. Each cat received 1 mL kg-1 of bupivacaine 2% or 2.5% (2 mg kg-1 or 2.5 mg kg-1; BUPI2 and BUPI2.5, respectively) via bilateral two-point TAP block before surgery (n = 6/group). Blood was collected using a dedicated catheter placed into a cephalic vein before (time 0) and at 5, 10, 15, 30, 60, 120, 240, 360, and 480 minutes after TAP injection. Plasma concentrations of bupivacaine were analysed using liquid chromatography-tandem mass spectrometry. Bupivacaine pharmacokinetics was described using a one-compartment model and non-compartmental analysis.

Citation Format(s)

Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy. / Garbin, M.; Benito, J.; Ruel, H.L.M. et al.
2022. Paper presented at Association of Veterinary Anaesthetists (AVA) Spring Meeting (2022), Nafplio, Greece.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (without host publication)peer-review