Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy

M. Garbin; J. Benito; H.L.M. Ruel; R. Watanabe; B.P. Monteiro; P. Cagnardi; P.V. Steagall

Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy

M. Garbin
, J. Benito
, H.L.M. Ruel
, R. Watanabe
, B.P. Monteiro
, P. Cagnardi
, P.V. Steagall

Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review

Abstract

This study describes the pharmacokinetics of bupivacaine following administration via an ultrasound-guided transversus abdominis plane (TAP) block in cats undergoing ovariohysterectomy.
Twelve healthy adult cats (3.7 ± 0.7 kg) were included in a randomized, prospective, blinded clinical trial. Anaesthetic protocol included acepromazine-buprenorphine-propofol-isoflurane-meloxicam. Each cat received 1 mL kg^-1 of bupivacaine 2% or 2.5% (2 mg kg^-1 or 2.5 mg kg^-1; BUPI2 and BUPI2.5, respectively) via bilateral two-point TAP block before surgery (n = 6/group). Blood was collected using a dedicated catheter placed into a cephalic vein before (time 0) and at 5, 10, 15, 30, 60, 120, 240, 360, and 480 minutes after TAP injection. Plasma concentrations of bupivacaine were analysed using liquid chromatography-tandem mass spectrometry. Bupivacaine pharmacokinetics was described using a one-compartment model and non-compartmental analysis.

Original language	English
Publication status	Published - 20 May 2022
Event	Association of Veterinary Anaesthetists (AVA) Spring Meeting (2022): Spring meeting 2022 - Fougaro Art Center, Nafplio, Greece Duration: 18 May 2022 → 20 May 2022 https://www.nafplio2022ava.org/proceedings https://www.nafplio2022ava.org/

Conference

Conference	Association of Veterinary Anaesthetists (AVA) Spring Meeting (2022)
Place	Greece
City	Nafplio
Period	18/05/22 → 20/05/22
Internet address	https://www.nafplio2022ava.org/proceedings https://www.nafplio2022ava.org/

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@conference{6f7d54c6d2a04b02b37435fadc3f94b8,

title = "Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy",

abstract = "This study describes the pharmacokinetics of bupivacaine following administration via an ultrasound-guided transversus abdominis plane (TAP) block in cats undergoing ovariohysterectomy. Twelve healthy adult cats (3.7 ± 0.7 kg) were included in a randomized, prospective, blinded clinical trial. Anaesthetic protocol included acepromazine-buprenorphine-propofol-isoflurane-meloxicam. Each cat received 1 mL kg-1 of bupivacaine 2\% or 2.5\% (2 mg kg-1 or 2.5 mg kg-1; BUPI2 and BUPI2.5, respectively) via bilateral two-point TAP block before surgery (n = 6/group). Blood was collected using a dedicated catheter placed into a cephalic vein before (time 0) and at 5, 10, 15, 30, 60, 120, 240, 360, and 480 minutes after TAP injection. Plasma concentrations of bupivacaine were analysed using liquid chromatography-tandem mass spectrometry. Bupivacaine pharmacokinetics was described using a one-compartment model and non-compartmental analysis.",

author = "M. Garbin and J. Benito and H.L.M. Ruel and R. Watanabe and B.P. Monteiro and P. Cagnardi and P.V. Steagall",

year = "2022",

month = may,

day = "20",

language = "English",

note = "Association of Veterinary Anaesthetists (AVA) Spring Meeting (2022) : Spring meeting 2022 ; Conference date: 18-05-2022 Through 20-05-2022",

url = "https://www.nafplio2022ava.org/proceedings, https://www.nafplio2022ava.org/",

}

Garbin, M, Benito, J, Ruel, HLM, Watanabe, R, Monteiro, BP, Cagnardi, P & Steagall, PV 2022, 'Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy', Paper presented at Association of Veterinary Anaesthetists (AVA) Spring Meeting (2022), Nafplio, Greece, 18/05/22 - 20/05/22.

Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy. / Garbin, M.; Benito, J.; Ruel, H.L.M. et al.
2022. Paper presented at Association of Veterinary Anaesthetists (AVA) Spring Meeting (2022), Nafplio, Greece.

Research output: Conference Papers › RGC 32 - Refereed conference paper (without host publication) › peer-review

TY - CONF

T1 - Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy

AU - Garbin, M.

AU - Benito, J.

AU - Ruel, H.L.M.

AU - Watanabe, R.

AU - Monteiro, B.P.

AU - Cagnardi, P.

AU - Steagall, P.V.

PY - 2022/5/20

Y1 - 2022/5/20

N2 - This study describes the pharmacokinetics of bupivacaine following administration via an ultrasound-guided transversus abdominis plane (TAP) block in cats undergoing ovariohysterectomy. Twelve healthy adult cats (3.7 ± 0.7 kg) were included in a randomized, prospective, blinded clinical trial. Anaesthetic protocol included acepromazine-buprenorphine-propofol-isoflurane-meloxicam. Each cat received 1 mL kg-1 of bupivacaine 2% or 2.5% (2 mg kg-1 or 2.5 mg kg-1; BUPI2 and BUPI2.5, respectively) via bilateral two-point TAP block before surgery (n = 6/group). Blood was collected using a dedicated catheter placed into a cephalic vein before (time 0) and at 5, 10, 15, 30, 60, 120, 240, 360, and 480 minutes after TAP injection. Plasma concentrations of bupivacaine were analysed using liquid chromatography-tandem mass spectrometry. Bupivacaine pharmacokinetics was described using a one-compartment model and non-compartmental analysis.

AB - This study describes the pharmacokinetics of bupivacaine following administration via an ultrasound-guided transversus abdominis plane (TAP) block in cats undergoing ovariohysterectomy. Twelve healthy adult cats (3.7 ± 0.7 kg) were included in a randomized, prospective, blinded clinical trial. Anaesthetic protocol included acepromazine-buprenorphine-propofol-isoflurane-meloxicam. Each cat received 1 mL kg-1 of bupivacaine 2% or 2.5% (2 mg kg-1 or 2.5 mg kg-1; BUPI2 and BUPI2.5, respectively) via bilateral two-point TAP block before surgery (n = 6/group). Blood was collected using a dedicated catheter placed into a cephalic vein before (time 0) and at 5, 10, 15, 30, 60, 120, 240, 360, and 480 minutes after TAP injection. Plasma concentrations of bupivacaine were analysed using liquid chromatography-tandem mass spectrometry. Bupivacaine pharmacokinetics was described using a one-compartment model and non-compartmental analysis.

M3 - RGC 32 - Refereed conference paper (without host publication)

T2 - Association of Veterinary Anaesthetists (AVA) Spring Meeting (2022)

Y2 - 18 May 2022 through 20 May 2022

ER -

Pharmacokinetics of bupivacaine following administration by an ultrasound-guided transversus abdominis plane block in cats undergoing ovariohysterectomy

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