Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia)

J. Soenens; H. Vermeersch; K. Baert; B. Vermeulen; H. Nelis; P. Butaye; P. De Herdt; J. P. Remon; P. De Backer

doi:10.1016/S1090-0233(98)80062-2

Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia)

J. Soenens, H. Vermeersch, K. Baert, B. Vermeulen, H. Nelis, P. Butaye, P. De Herdt, J. P. Remon, P. De Backer

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

11 Citations (Scopus)

Abstract

The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150 mg.kg^-1 amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66 min and showed a distribution volume of 0.9 L.kg^-1. The absolute oral bioavailability of amoxycillin was 50.1%. A 5-day drinking water treatment with amoxycillin (1500 mg.L^-1, corresponding to 112.0 mg.kg^-1.day^-1 during day-light hours) significantly reduced the post-inoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls.

Original language	English
Pages (from-to)	59-65
Journal	The Veterinary Journal
Volume	156
Issue number	1
DOIs	https://doi.org/10.1016/S1090-0233(98)80062-2
Publication status	Published - 1998
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected]

Research Keywords

Amoxycillin
Efficacy
Pharmacokinetics
Pigeon
Streptococcus bovis

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title = "Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia)",

abstract = "The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150 mg.kg-1 amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66 min and showed a distribution volume of 0.9 L.kg-1. The absolute oral bioavailability of amoxycillin was 50.1%. A 5-day drinking water treatment with amoxycillin (1500 mg.L-1, corresponding to 112.0 mg.kg-1.day-1 during day-light hours) significantly reduced the post-inoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls.",

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author = "J. Soenens and H. Vermeersch and K. Baert and B. Vermeulen and H. Nelis and P. Butaye and {De Herdt}, P. and Remon, {J. P.} and {De Backer}, P.",

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doi = "10.1016/S1090-0233(98)80062-2",

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T1 - Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia)

AU - Soenens, J.

AU - Vermeersch, H.

AU - Baert, K.

AU - Vermeulen, B.

AU - Nelis, H.

AU - Butaye, P.

AU - De Herdt, P.

AU - Remon, J. P.

AU - De Backer, P.

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected]

PY - 1998

Y1 - 1998

N2 - The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150 mg.kg-1 amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66 min and showed a distribution volume of 0.9 L.kg-1. The absolute oral bioavailability of amoxycillin was 50.1%. A 5-day drinking water treatment with amoxycillin (1500 mg.L-1, corresponding to 112.0 mg.kg-1.day-1 during day-light hours) significantly reduced the post-inoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls.

AB - The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150 mg.kg-1 amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66 min and showed a distribution volume of 0.9 L.kg-1. The absolute oral bioavailability of amoxycillin was 50.1%. A 5-day drinking water treatment with amoxycillin (1500 mg.L-1, corresponding to 112.0 mg.kg-1.day-1 during day-light hours) significantly reduced the post-inoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls.

KW - Amoxycillin

KW - Efficacy

KW - Pharmacokinetics

KW - Pigeon

KW - Streptococcus bovis

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U2 - 10.1016/S1090-0233(98)80062-2

DO - 10.1016/S1090-0233(98)80062-2

M3 - RGC 21 - Publication in refereed journal

C2 - 9691852

SN - 1090-0233

VL - 156

SP - 59

EP - 65

JO - The Veterinary Journal

JF - The Veterinary Journal

IS - 1

ER -

Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia)

Abstract

Bibliographical note

Research Keywords

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