Abstract
Herein, a class of pH-responsive spherical nucleic acid (SNA) nanostructures prepared by functionalizing gold nanoparticles with DNA nanodevices is presented, which can perform duplex-to-triplex transition upon pH change via pH-sensitive parallel Hoogsteen interactions. The SNA nanostructures exhibit tunable pH sensitivity and a highly rapid and reversible allosteric effect. Furthermore, they can exactly image lysosomes in living cells. We next engineered pH-triggered doxorubicin(Dox)-SNA conjugates that could deliver Dox molecules into cancer cells and achieve pH-dependent drug release.
| Original language | English |
|---|---|
| Pages (from-to) | 3520-3523 |
| Journal | Chemical Communications |
| Volume | 54 |
| Issue number | 28 |
| Online published | 8 Mar 2018 |
| DOIs | |
| Publication status | Published - 11 Apr 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Fingerprint
Dive into the research topics of 'PH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver