pH Controlled Release of Chromone from Chromone-Fe3O4 Nanoparticles

Baodui Wang; Chenjie Xu; Jin Xie; Zhengyin Yang; Shouheng Sun

doi:10.1021/ja806519m

pH Controlled Release of Chromone from Chromone-Fe₃O₄ Nanoparticles

Baodui Wang
, Chenjie Xu
, Jin Xie
, Zhengyin Yang
, Shouheng Sun

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

161 Citations (Scopus)

Abstract

We report a new strategy for coupling chromone to Fe₃O₄ nanoparticles. The chromone-Fe₃O₄ NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 μg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe₃O₄ conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe₃O₄ NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications. Copyright © 2008 American Chemical Society.

Original language	English
Pages (from-to)	14436-14437
Journal	Journal of the American Chemical Society
Volume	130
Issue number	44
Online published	8 Oct 2008
DOIs	https://doi.org/10.1021/ja806519m
Publication status	Published - 5 Nov 2008
Externally published	Yes

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title = "pH Controlled Release of Chromone from Chromone-Fe3O4 Nanoparticles",

abstract = "We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 μg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications. Copyright {\textcopyright} 2008 American Chemical Society.",

author = "Baodui Wang and Chenjie Xu and Jin Xie and Zhengyin Yang and Shouheng Sun",

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T1 - pH Controlled Release of Chromone from Chromone-Fe3O4 Nanoparticles

AU - Wang, Baodui

AU - Xu, Chenjie

AU - Xie, Jin

AU - Yang, Zhengyin

AU - Sun, Shouheng

PY - 2008/11/5

Y1 - 2008/11/5

N2 - We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 μg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications. Copyright © 2008 American Chemical Society.

AB - We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 μg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications. Copyright © 2008 American Chemical Society.

UR - https://www.scopus.com/pages/publications/55549138774

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U2 - 10.1021/ja806519m

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M3 - RGC 21 - Publication in refereed journal

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SN - 0002-7863

VL - 130

SP - 14436

EP - 14437

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 44

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