TY - JOUR
T1 - Perylene Diimide Oligomer Nanoparticles with Ultrahigh Photothermal Conversion Efficiency for Cancer Theranostics
AU - Gong, Qiuyu
AU - Xing, Jie
AU - Huang, Yinjuan
AU - Wu, Aiguo
AU - Yu, Jing
AU - Zhang, Qichun
PY - 2020/3/16
Y1 - 2020/3/16
N2 - Developing one agent that has reasonable stability and ultrahigh photothermal conversion efficiency (PTCE) for near-infrared (NIR) photothermal cancer treatment remains a great challenge, but is highly desirable. In this research, we developed a perylene diimide (PDI)-based oligomer (OPDI) through coupling monomeric PDI derivatives together. OPDI exhibited slightly red-shifted absorption at NIR region compared with monomeric PDI. More importantly, the self-assembled OPDI nanoparticles not only exhibited high stability and preferable biocompatibility, but also possessed an ultrahigh PTCE (up to 79.8%, higher than many other photothermal agents reported before). This OPDI photothermal agent has been demonstrated to exhibit excellent therapeutic effects. Our research provides a guide for the exploitation of photothermal agents with ultrahigh PTCE.© 2020 American Chemical Society
AB - Developing one agent that has reasonable stability and ultrahigh photothermal conversion efficiency (PTCE) for near-infrared (NIR) photothermal cancer treatment remains a great challenge, but is highly desirable. In this research, we developed a perylene diimide (PDI)-based oligomer (OPDI) through coupling monomeric PDI derivatives together. OPDI exhibited slightly red-shifted absorption at NIR region compared with monomeric PDI. More importantly, the self-assembled OPDI nanoparticles not only exhibited high stability and preferable biocompatibility, but also possessed an ultrahigh PTCE (up to 79.8%, higher than many other photothermal agents reported before). This OPDI photothermal agent has been demonstrated to exhibit excellent therapeutic effects. Our research provides a guide for the exploitation of photothermal agents with ultrahigh PTCE.© 2020 American Chemical Society
KW - perylene diimides
KW - phototheranostics
KW - photothermal agent
KW - photothermal conversion efficiency
KW - self-assembly
UR - http://www.scopus.com/inward/record.url?scp=85089273922&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85089273922&origin=recordpage
U2 - 10.1021/acsabm.9b01187
DO - 10.1021/acsabm.9b01187
M3 - RGC 21 - Publication in refereed journal
C2 - 35021651
SN - 2576-6422
VL - 3
SP - 1607
EP - 1615
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 3
ER -
