TY - JOUR
T1 - Peroxidase-mimicking evodiamine/indocyanine green nanoliposomes for multimodal imaging-guided theranostics for oral squamous cell carcinoma
AU - Wei, Zheng
AU - Zou, Huihui
AU - Liu, Gongyuan
AU - Song, Chuanhui
AU - Tang, Chuanchao
AU - Chen, Sheng
AU - Zhang, Guorong
AU - Ran, Jianchuan
AU - Wang, Yufeng
AU - Yin, Xiteng
AU - Cai, Yu
AU - Han, Wei
PY - 2021/7
Y1 - 2021/7
N2 - Here, evodiamine (EVO) and the photosensitizer indocyanine green (ICG) were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma (OSCC). EVO, as an active component extracted from traditional Chinese medicine, not only functioned as an antitumor chemotherapeutic agent but was also capable of 68Ga-chelation, thus working as a contrast agent for positron emission tomography/computed tomography (PET/CT) imaging. Moreover, EVO could exhibit peroxidase-like catalytic activity, converting endogenous tumor H2O2 into cytotoxic reactive oxygen species (ROS), enabling Chemo catalytic therapy beyond the well-known chemotherapy effect of EVO. As proven by in vitro and in vivo experiments, guided by optical imaging and PET/CT imaging, we show that the theragnostic liposomes have a significant inhibiting effect on in situ tongue tumor through photodynamic therapy combined with chemodynamic chemotherapy.
AB - Here, evodiamine (EVO) and the photosensitizer indocyanine green (ICG) were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma (OSCC). EVO, as an active component extracted from traditional Chinese medicine, not only functioned as an antitumor chemotherapeutic agent but was also capable of 68Ga-chelation, thus working as a contrast agent for positron emission tomography/computed tomography (PET/CT) imaging. Moreover, EVO could exhibit peroxidase-like catalytic activity, converting endogenous tumor H2O2 into cytotoxic reactive oxygen species (ROS), enabling Chemo catalytic therapy beyond the well-known chemotherapy effect of EVO. As proven by in vitro and in vivo experiments, guided by optical imaging and PET/CT imaging, we show that the theragnostic liposomes have a significant inhibiting effect on in situ tongue tumor through photodynamic therapy combined with chemodynamic chemotherapy.
KW - Evodiamine
KW - Oral squamous cell carcinoma
KW - Peroxidase-mimicking
KW - Trimodal antitumor therapy
UR - http://www.scopus.com/inward/record.url?scp=85099266741&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85099266741&origin=recordpage
U2 - 10.1016/j.bioactmat.2020.12.016
DO - 10.1016/j.bioactmat.2020.12.016
M3 - RGC 21 - Publication in refereed journal
C2 - 33511313
SN - 2452-199X
VL - 6
SP - 2144
EP - 2157
JO - Bioactive Materials
JF - Bioactive Materials
IS - 7
ER -
