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Abstract
Motivation: CEST MRI is often limited in its application due to its time-consuming nature. Also, multiple saturation frequency offsets are required to accurately measure CEST effects.
Goal(s): Accelerate CEST imaging by undersampling k-space of each frequency offset below Nyquist rate.
Approach: Periodically rotated spiral sampling (PRSS) is proposed to make adjacent offsets capture different k-space subregions. Besides, a multi-offset transformer reconstruction (MoTR) network is further presented to fuse complementary information from multiple offsets.
Results: Compared to fully-sampled images, reconstructed images using our method can achieve an average SSIM/MAE of 0.9899/0.0032, resulting a coefficient R value of 0.93/0.95 in terms of CEST signals at -3.5ppm/+3.5ppm.
Impact: Our method can realize 4× acceleration of CEST imaging without sacrificing down-stream CEST analysis performance. Besides, our method has the potential to work on MRI scanner for CEST acceleration, which can further expand the application of CEST MRI.
Goal(s): Accelerate CEST imaging by undersampling k-space of each frequency offset below Nyquist rate.
Approach: Periodically rotated spiral sampling (PRSS) is proposed to make adjacent offsets capture different k-space subregions. Besides, a multi-offset transformer reconstruction (MoTR) network is further presented to fuse complementary information from multiple offsets.
Results: Compared to fully-sampled images, reconstructed images using our method can achieve an average SSIM/MAE of 0.9899/0.0032, resulting a coefficient R value of 0.93/0.95 in terms of CEST signals at -3.5ppm/+3.5ppm.
Impact: Our method can realize 4× acceleration of CEST imaging without sacrificing down-stream CEST analysis performance. Besides, our method has the potential to work on MRI scanner for CEST acceleration, which can further expand the application of CEST MRI.
| Original language | English |
|---|---|
| Publication status | Published - 9 May 2024 |
| Event | 2024 ISMRM & ISMRT Annual Meeting & Exhibition - Suntec Singapore Convention & Exhibition Centre, Singapore Duration: 4 May 2024 → 9 May 2024 https://www.ismrm.org/24m/ |
Conference
| Conference | 2024 ISMRM & ISMRT Annual Meeting & Exhibition |
|---|---|
| Country/Territory | Singapore |
| Period | 4/05/24 → 9/05/24 |
| Internet address |
Funding
Authors would like to acknowledge the funding supports from Research Grants Council (11102218, 11200422, RFS2223-1S02, C1134-20G); City University of Hong Kong (7005433, 7005626, 9609307, 9610560 and 9610616), National Natural Science Foundation of China (81871409), Tung Biomedical Sciences Centre, and Hong Kong Centre for Cerebro-cardiovascular Health Engineering.
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