Perfluorooctanesulfonate and related fluorochemicals in human blood samples from China

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Leo W. Y. Yeung
  • M. K. So
  • Guibin Jiang
  • S. Taniyasu
  • N. Yamashita
  • And 6 others
  • Maoyong Song
  • Yongning Wu
  • Jingguang Li
  • J. P. Giesy
  • K. S. Guruge
  • Paul K. S. Lam

Detail(s)

Original languageEnglish
Pages (from-to)715-720
Journal / PublicationEnvironmental Science and Technology
Volume40
Issue number3
Publication statusPublished - 1 Feb 2006

Abstract

Perfluorooctanesulfonylfluoride (POSF)-based compounds have been manufactured and used in a variety of industrial applications. These compounds degrade to perfluorooctanesulfonate (PFOS) which is regarded as a persistent end-stage metabolite and is found to accumulate in tissues of humans and wildlife. PFOS, perfluorohexanesulfonate (PFHxS), perfluorooctanoate (PFOA), and perfluorooctanesulfonamide (PFOSA) have been found in human sera from the United States. In this study, concentrations of PFHxS, perfluorobutanesulfonate (PFBS), PFOS, perfluorohexanoic acid (PFHxA), PFOA, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and PFOSA were measured in 85 samples of whole human blood collected from nine cities (eight provinces) in China, including Shenyang (Liaoning), Beijing (Hebei), Zhengzhou (Henan), Jintan (Jiangsu), Wuhan (Hubei), Zhoushan (Zhejiang), Guiyang (Guizhou), Xiamen (Fujian), and Fuzhou (Fujian). Among the 10 perfluorinated compounds (PFCs) measured, PFOS was the predominant compound. The mean concentration of PFOS was greatest in samples collected from Shenyang (79.2 ng/mL) and least in samples from Jintan (3.72 ng/mL). PFHxS was the next most abundant perfluorochemical in the samples. No age-related differences in the concentrations of PFOA, PFOS, PFOSA, and PFHxS were observed. Gender-related differences were found, with males higher for PFOS and PFHxS, and females higher in PFUnOA. Concentrations of PFHxS were positively correlated with those of PFOS, while concentrations of PFNA, PFOA, and PFUnOA were positively correlated with those of PFOA. There were differences in the concentration profiles (percentage composition) of various PFCs in the samples among the nine cities. © 2006 American Chemical Society.

Citation Format(s)

Perfluorooctanesulfonate and related fluorochemicals in human blood samples from China. / Yeung, Leo W. Y.; So, M. K.; Jiang, Guibin; Taniyasu, S.; Yamashita, N.; Song, Maoyong; Wu, Yongning; Li, Jingguang; Giesy, J. P.; Guruge, K. S.; Lam, Paul K. S.

In: Environmental Science and Technology, Vol. 40, No. 3, 01.02.2006, p. 715-720.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review