Perfluorocarbon Encapsulated IR780@Liposome for enhanced near-infra photodynamic antibacterial therapy against hypixia

Photodynamic antibacterial therapy (PDT) is a kind of therapy relay on the ability of converting oxygen around into cytotoxic singlet oxygen (¹O₂) to kill bacterium. It usually consist of three components: a photosensitizer (PS), light, and tissue oxygen. The light-activated PS transfers its excited-stated energy to the environmental oxygen for generating reactive oxygen species (ROS). However, antibacterial photodynamic theray is often limited by surrounding oxygen supply, in addition, there remains an inadequate oxygen capacity especially in tissue infected, and thus decrease the antibacterial activity. Perfluorohexane (PFH) nanodroplet has a high oxygen content that can enrich oxygen of photosensitizer around. Therefore, PFH can be used to form an oxygen self-enriching photodynamic therapy system which can not only overcome the problem of oxygen insufficiency but also prolong ¹O₂ lifetime. Hence, we encapsulated perfluorohexne into a photosensitizer (IR780) loaded liposome film to fabricate an antibacterial platform and then observe its bacterium resistivity and cellular compatibility. And the antibacterial PDT efficiency is improved considerably in consequence.