Peptide-directed binding of quantum dots to integrins in human fibroblast

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

15 Scopus Citations
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Author(s)

  • Peng Shi
  • Hongfeng Chen
  • Michael R. Cho
  • Michael A. Stroscio

Detail(s)

Original languageEnglish
Pages (from-to)15-19
Journal / PublicationIEEE Transactions on Nanobioscience
Volume5
Issue number1
Publication statusPublished - Mar 2006
Externally publishedYes

Abstract

There is currently a major international effort aimed at integrating semiconductor nanostructures with biological structures. This paper reports the use of peptide sequences with certain motifs like artinine-glycine-aspartic acid (RGD) and leucine-aspartic acid-valine (LDV) to functionalize zinc sulfide (ZnS)-capped cadmiun selenide (CdSe) quantum dots, so that the quantum dot-peptide complexes selectively bind to integrins on HT1080 human fibrosarcoma cells membrane. In this way, an interface between semiconductor nanocrystals and subcellular components was achieved, and the distribution pattern of RGD and LDV receptors on HT1080 cell membranes is revealed. These findings point the way to using a wide class of peptide-functionalized semiconductor quantum dots for the study of cellular processes involving integrins. © 2006 IEEE.

Research Area(s)

  • Human fibroblasts, Peptides, Photoluminescence, Quantum dots (QDs)

Citation Format(s)

Peptide-directed binding of quantum dots to integrins in human fibroblast. / Shi, Peng; Chen, Hongfeng; Cho, Michael R.; Stroscio, Michael A.

In: IEEE Transactions on Nanobioscience, Vol. 5, No. 1, 03.2006, p. 15-19.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review