Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

93 Scopus Citations
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Author(s)

  • Ganchao Chen
  • Raoul Peltier
  • Haipeng Lei
  • Jun Chen
  • Yi Hu

Detail(s)

Original languageEnglish
Pages (from-to)11204-11209
Journal / PublicationACS Applied Materials & Interfaces
Volume8
Issue number18
Online published22 Apr 2016
Publication statusPublished - 11 May 2016

Abstract

A stimuli-responsive drug delivery system (DDS) with bioactive surface is constructed by end-capping mesoporous silica nanoparticles (MSNs) with functional peptide-coated gold nanoparticles (GNPs). MSNs are first functionalized with acid-labile α-amide-β-carboxyl groups to carry negative charges, and then capped with positively charged GNPs that are decorated with oligo-lysine-containing peptide. The resulting hybrid delivery system exhibits endo/lysosomal pH triggered drug release, and the incorporation of RGD peptide facilitates targeting delivery to αvβ3 integrin overexpressing cancer cells. The system can serve as a platform for preparing diversified multifunctional nanocomposites using various functional inorganic nanoparticles and bioactive peptides.

Research Area(s)

  • charge reversal, controlled release, gold nanoparticles, peptides, targeted delivery

Citation Format(s)

Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery. / Chen, Ganchao; Xie, Yusheng; Peltier, Raoul et al.
In: ACS Applied Materials & Interfaces, Vol. 8, No. 18, 11.05.2016, p. 11204-11209.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review