Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
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Detail(s)
Original language | English |
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Pages (from-to) | 11204-11209 |
Journal / Publication | ACS Applied Materials & Interfaces |
Volume | 8 |
Issue number | 18 |
Online published | 22 Apr 2016 |
Publication status | Published - 11 May 2016 |
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Abstract
A stimuli-responsive drug delivery system (DDS) with bioactive surface is constructed by end-capping mesoporous silica nanoparticles (MSNs) with functional peptide-coated gold nanoparticles (GNPs). MSNs are first functionalized with acid-labile α-amide-β-carboxyl groups to carry negative charges, and then capped with positively charged GNPs that are decorated with oligo-lysine-containing peptide. The resulting hybrid delivery system exhibits endo/lysosomal pH triggered drug release, and the incorporation of RGD peptide facilitates targeting delivery to αvβ3 integrin overexpressing cancer cells. The system can serve as a platform for preparing diversified multifunctional nanocomposites using various functional inorganic nanoparticles and bioactive peptides.
Research Area(s)
- charge reversal, controlled release, gold nanoparticles, peptides, targeted delivery
Citation Format(s)
Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery. / Chen, Ganchao; Xie, Yusheng; Peltier, Raoul et al.
In: ACS Applied Materials & Interfaces, Vol. 8, No. 18, 11.05.2016, p. 11204-11209.
In: ACS Applied Materials & Interfaces, Vol. 8, No. 18, 11.05.2016, p. 11204-11209.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review