TY - JOUR
T1 - Peptide microarray for high-throughput determination of phosphatase specificity and biology
AU - Sun, Hongyan
AU - Lu, Candy H. S.
AU - Uttamchandani, Mahesh
AU - Xia, Yun
AU - Liou, Yih-Cherng
AU - Yao, Shao Q.
PY - 2008/2/15
Y1 - 2008/2/15
N2 - Identifying phosphatase substrates: A peptide microarray has been developed for the high-throughput study of Ser/Thr phosphatases. Putative peptide substrates, upon immobilization onto a glass slide, could be used to obtain kinetic information and identify the substrate preferences of a Ser/Thr phosphatase (see schematic representation); with this information, new biology of the enzyme could be discovered. (Figure Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
AB - Identifying phosphatase substrates: A peptide microarray has been developed for the high-throughput study of Ser/Thr phosphatases. Putative peptide substrates, upon immobilization onto a glass slide, could be used to obtain kinetic information and identify the substrate preferences of a Ser/Thr phosphatase (see schematic representation); with this information, new biology of the enzyme could be discovered. (Figure Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
KW - Microarrays
KW - Peptides
KW - Phosphatases
KW - Phosphorylation
KW - Substrate specificity
UR - http://www.scopus.com/inward/record.url?scp=41049117046&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-41049117046&origin=recordpage
U2 - 10.1002/anie.200703473
DO - 10.1002/anie.200703473
M3 - RGC 21 - Publication in refereed journal
C2 - 18203220
SN - 1433-7851
VL - 47
SP - 1698
EP - 1702
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 9
ER -