Palladium-catalysed mono-α-alkenylation of ketones with alkenyl tosylates

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Chien-Wei Chiang
  • Pui Ying Choy
  • Fuk Yee Kwong
  • Aiwen Lei

Detail(s)

Original languageEnglish
Pages (from-to)952-955
Number of pages4
Journal / PublicationChemical Communications (London)
Volume53
Issue number5
Online published19 Dec 2016
Publication statusPublished - 16 Jan 2017
Externally publishedYes

Abstract

The first example of palladium-catalysed selective mono-α-alkenylation of ketones with alkenyl tosylates is described. In the presence of a Pd/XPhos catalyst system (0.1–1.0 mol%), the reaction provides mono-α-alkenylated ketones in good yields and exhibits excellent substrate tolerance. Highly congested, tri- and tetra-substituted alkenyl tosylates react smoothly and even problematic heteroaryl and aliphatic ketones are applicable substrates. Notably, small β,γ-unsaturated ketones are successfully prepared using acetone as a simple three-carbon feedstock. © The Royal Society of Chemistry 2017

Citation Format(s)

Palladium-catalysed mono-α-alkenylation of ketones with alkenyl tosylates. / Wu, Yong; Fu, Wai Chung; Chiang, Chien-Wei et al.
In: Chemical Communications (London), Vol. 53, No. 5, 16.01.2017, p. 952-955.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review