Palladium-catalyzed asymmetric intermolecular cyclization

Jian Hu; Hajime Hirao; Yongxin Li; Jianrong Zhou

doi:10.1002/anie.201303753

Palladium-catalyzed asymmetric intermolecular cyclization

Jian Hu
, Hajime Hirao
, Yongxin Li
, Jianrong Zhou^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

84 Citations (Scopus)

Abstract

Domino cyclization: Alkylpalladium intermediates in an asymmetric Heck reaction were intercepted by a second alkene to give tricyclic products with high enantioselectivity (see scheme; Boc=tert-butoxycarbonyl). The method was applied to the asymmetric synthesis of a precursor of (-)-martinellic acid, a folk eye medicine in South America. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	8676-8680
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	33
DOIs	https://doi.org/10.1002/anie.201303753
Publication status	Published - 12 Aug 2013
Externally published	Yes

Research Keywords

asymmetric synthesis
cyclization
domino reactions
Heck reaction
palladium catalysis

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10.1002/anie.201303753

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title = "Palladium-catalyzed asymmetric intermolecular cyclization",

abstract = "Domino cyclization: Alkylpalladium intermediates in an asymmetric Heck reaction were intercepted by a second alkene to give tricyclic products with high enantioselectivity (see scheme; Boc=tert-butoxycarbonyl). The method was applied to the asymmetric synthesis of a precursor of (-)-martinellic acid, a folk eye medicine in South America. Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

keywords = "asymmetric synthesis, cyclization, domino reactions, Heck reaction, palladium catalysis",

author = "Jian Hu and Hajime Hirao and Yongxin Li and Jianrong Zhou",

year = "2013",

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day = "12",

doi = "10.1002/anie.201303753",

language = "English",

volume = "52",

pages = "8676--8680",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

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TY - JOUR

T1 - Palladium-catalyzed asymmetric intermolecular cyclization

AU - Hu, Jian

AU - Hirao, Hajime

AU - Li, Yongxin

AU - Zhou, Jianrong

PY - 2013/8/12

Y1 - 2013/8/12

N2 - Domino cyclization: Alkylpalladium intermediates in an asymmetric Heck reaction were intercepted by a second alkene to give tricyclic products with high enantioselectivity (see scheme; Boc=tert-butoxycarbonyl). The method was applied to the asymmetric synthesis of a precursor of (-)-martinellic acid, a folk eye medicine in South America. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - Domino cyclization: Alkylpalladium intermediates in an asymmetric Heck reaction were intercepted by a second alkene to give tricyclic products with high enantioselectivity (see scheme; Boc=tert-butoxycarbonyl). The method was applied to the asymmetric synthesis of a precursor of (-)-martinellic acid, a folk eye medicine in South America. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - asymmetric synthesis

KW - cyclization

KW - domino reactions

KW - Heck reaction

KW - palladium catalysis

UR - https://www.scopus.com/pages/publications/84882350214

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84882350214&origin=recordpage

U2 - 10.1002/anie.201303753

DO - 10.1002/anie.201303753

M3 - RGC 21 - Publication in refereed journal

SN - 1433-7851

VL - 52

SP - 8676

EP - 8680

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -

Palladium-catalyzed asymmetric intermolecular cyclization

Abstract

Research Keywords

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