P53 binding protein 1 foci as a biomarker of DNA double strand breaks induced by ionizing radiation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

3 Scopus Citations
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Author(s)

  • C. K M Ng
  • M. Y P Wong
  • R. K K Lam
  • J. P Y Ho
  • S. K. Chiu

Detail(s)

Original languageEnglish
Pages (from-to)116-120
Journal / PublicationNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume660
Issue number1
Publication statusPublished - 21 Dec 2011

Abstract

Foci of p53 binding protein 1 (53 BP1) have been used as a biomarker of DNA double-strand breaks (DSBs) in cells induced by ionizing radiations. 53 BP1 was shown to relocalize into foci shortly after irradiation, with the number of foci closely paralleling the number of DNA DSBs. However, consensus on criteria in terms of the numbers of 53 BP1 foci to define cells damaged by direct irradiation or by bystander signals has not been reached, which is partly due to the presence of 53 BP1 also in normal cells. The objective of the present work was to study the changes in the distribution of cells with different numbers of 53 BP1 foci in a cell population after low-dose ionizing irradiation (

Research Area(s)

  • 53 BP1, Alpha particle, Bysta effect, Radiation effect

Citation Format(s)

P53 binding protein 1 foci as a biomarker of DNA double strand breaks induced by ionizing radiation. / Ng, C. K M; Wong, M. Y P; Lam, R. K K; Ho, J. P Y; Chiu, S. K.; Yu, K. N.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 660, No. 1, 21.12.2011, p. 116-120.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review