Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

  • Defang Li
  • Jin Liu
  • Baosheng Guo
  • Chao Liang
  • Lei Dang
  • Cheng Lu
  • Xiaojuan He
  • Hilda Yeuk-Siu Cheung
  • Liang Xu
  • Changwei Lu
  • Bing He
  • Biao Liu
  • Atik Badshah Shaikh
  • Fangfei Li
  • Luyao Wang
  • Zhijun Yang
  • Songlin Peng
  • Zongkang Zhang
  • Bao-Ting Zhang
  • Xiaohua Pan
  • Airong Qian
  • Peng Shang
  • Lianbo Xiao
  • Baohong Jiang
  • Chris Kong-Chu Wong
  • Jiake Xu
  • Zhaoxiang Bian
  • Zicai Liang
  • De-An Guo
  • Hailong Zhu
  • Weihong Tan
  • Aiping Lu
  • Ge Zhang

Detail(s)

Original languageEnglish
Article number10872
Journal / PublicationNature Communications
Volume7
Publication statusPublished - 7 Mar 2016

Link(s)

Abstract

Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased osteoclastic miR-214-3p associates with both elevated serum exosomal miR-214-3p and reduced bone formation in elderly women with fractures and in ovariectomized (OVX) mice. Osteoclast-specific miR-214-3p knock-in mice have elevated serum exosomal miR-214-3p and reduced bone formation that is rescued by osteoclast-targeted antagomir-214-3p treatment. We further demonstrate that osteoclast-derived exosomal miR-214-3p is transferred to osteoblasts to inhibit osteoblast activity in vitro and reduce bone formation in vivo. Moreover, osteoclast-targeted miR-214-3p inhibition promotes bone formation in ageing OVX mice. Collectively, our results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation. Inhibition of miR-214-3p in osteoclasts may be a strategy for treating skeletal disorders involving a reduction in bone formation.

Research Area(s)

Citation Format(s)

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. / Li, Defang; Liu, Jin; Guo, Baosheng; Liang, Chao; Dang, Lei; Lu, Cheng; He, Xiaojuan; Cheung, Hilda Yeuk-Siu; Xu, Liang; Lu, Changwei; He, Bing; Liu, Biao; Shaikh, Atik Badshah; Li, Fangfei; Wang, Luyao; Yang, Zhijun; Au, Doris Wai-Ting; Peng, Songlin; Zhang, Zongkang; Zhang, Bao-Ting; Pan, Xiaohua; Qian, Airong; Shang, Peng; Xiao, Lianbo; Jiang, Baohong; Wong, Chris Kong-Chu; Xu, Jiake; Bian, Zhaoxiang; Liang, Zicai; Guo, De-An; Zhu, Hailong; Tan, Weihong; Lu, Aiping; Zhang, Ge.

In: Nature Communications, Vol. 7, 10872, 07.03.2016.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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