Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen-Xiu Ni; Wai-Lun Man; Shek-Man Yiu; Man Ho; Myra Ting-Wai Cheung; Chi-Chiu Ko; Chi-Ming Che; Yun-Wah Lam; Tai-Chu Lau

doi:10.1039/c2sc01031c

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen-Xiu Ni, Wai-Lun Man, Shek-Man Yiu, Man Ho, Myra Ting-Wai Cheung, Chi-Chiu Ko, Chi-Ming Che, Yun-Wah Lam^*, Tai-Chu Lau^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

53 Citations (Scopus)

Abstract

Eight new nitridoosmium(vi) complexes with the general formula [Os ^VI(N)Cl ₃(Hazole) ₂] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	1582-1588
Journal	Chemical Science
Volume	3
Issue number	5
DOIs	https://doi.org/10.1039/c2sc01031c
Publication status	Published - May 2012

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title = "Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents",

abstract = "Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. {\textcopyright} 2012 The Royal Society of Chemistry.",

author = "Wen-Xiu Ni and Wai-Lun Man and Shek-Man Yiu and Man Ho and Cheung, {Myra Ting-Wai} and Chi-Chiu Ko and Chi-Ming Che and Yun-Wah Lam and Tai-Chu Lau",

year = "2012",

month = may,

doi = "10.1039/c2sc01031c",

language = "English",

volume = "3",

pages = "1582--1588",

journal = "Chemical Science",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Osmium(vi) nitrido complexes bearing azole heterocycles

T2 - A new class of antitumor agents

AU - Ni, Wen-Xiu

AU - Man, Wai-Lun

AU - Yiu, Shek-Man

AU - Ho, Man

AU - Cheung, Myra Ting-Wai

AU - Ko, Chi-Chiu

AU - Che, Chi-Ming

AU - Lam, Yun-Wah

AU - Lau, Tai-Chu

PY - 2012/5

Y1 - 2012/5

N2 - Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.

AB - Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84859336852&origin=recordpage

U2 - 10.1039/c2sc01031c

DO - 10.1039/c2sc01031c

M3 - RGC 21 - Publication in refereed journal

SN - 2041-6520

VL - 3

SP - 1582

EP - 1588

JO - Chemical Science

JF - Chemical Science

IS - 5

ER -

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Abstract

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