Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen-Xiu Ni; Wai-Lun Man; Shek-Man Yiu; Man Ho; Myra Ting-Wai Cheung; Chi-Chiu Ko; Chi-Ming Che; Yun-Wah Lam; Tai-Chu Lau

doi:10.1039/c2sc01031c

Author(s)

Wen-Xiu Ni
Wai-Lun Man
Shek-Man Yiu
Man Ho
Myra Ting-Wai Cheung
Chi-Ming Che
Yun-Wah Lam
Tai-Chu Lau

Detail(s)

Original language	English
Pages (from-to)	1582-1588
Journal / Publication	Chemical Science
Volume	3
Issue number	5
Publication status	Published - May 2012

Link(s)

DOI	DOI https://doi.org/10.1039/c2sc01031c Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84859336852&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(c78e61a9-d910-4eb5-87a0-b1bb23e6a269).html

Abstract

Eight new nitridoosmium(vi) complexes with the general formula [Os ^VI(N)Cl ₃(Hazole) ₂] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.

Research Area(s)

SDG 3 - Good Health and Well-being

Citation Format(s)

[ RIS ] [ BibTeX ]

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents. / Ni, Wen-Xiu; Man, Wai-Lun; Yiu, Shek-Man et al.
In: Chemical Science, Vol. 3, No. 5, 05.2012, p. 1582-1588.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Ni, W-X, Man, W-L, Yiu, S-M, Ho, M, Cheung, MT-W, Ko, C-C, Che, C-M, Lam, Y-W & Lau, T-C 2012, 'Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents', Chemical Science, vol. 3, no. 5, pp. 1582-1588. https://doi.org/10.1039/c2sc01031c

Ni, W.-X., Man, W.-L., Yiu, S.-M., Ho, M., Cheung, M. T.-W., Ko, C.-C., Che, C.-M., Lam, Y.-W., & Lau, T.-C. (2012). Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents. Chemical Science, 3(5), 1582-1588. https://doi.org/10.1039/c2sc01031c

Ni WX, Man WL, Yiu SM, Ho M, Cheung MTW, Ko CC et al. Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents. Chemical Science. 2012 May;3(5):1582-1588. doi: 10.1039/c2sc01031c

Ni, Wen-Xiu ; Man, Wai-Lun ; Yiu, Shek-Man et al. / Osmium(vi) nitrido complexes bearing azole heterocycles : A new class of antitumor agents. In: Chemical Science. 2012 ; Vol. 3, No. 5. pp. 1582-1588.

Osmium(vi) nitrido complexes bearing azole heterocycles : A new class of antitumor agents