Osmium(vi) nitrido complexes bearing azole heterocycles : A new class of antitumor agents

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Wen-Xiu Ni
  • Wai-Lun Man
  • Shek-Man Yiu
  • Man Ho
  • Myra Ting-Wai Cheung
  • Chi-Ming Che
  • Yun-Wah Lam
  • Tai-Chu Lau

Detail(s)

Original languageEnglish
Pages (from-to)1582-1588
Journal / PublicationChemical Science
Volume3
Issue number5
Publication statusPublished - May 2012

Abstract

Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.

Citation Format(s)

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents. / Ni, Wen-Xiu; Man, Wai-Lun; Yiu, Shek-Man et al.
In: Chemical Science, Vol. 3, No. 5, 05.2012, p. 1582-1588.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review