Osmium(vi) complexes as a new class of potential anti-cancer agents

Wen-Xiu Ni; Wai-Lun Man; Myra Ting-Wai Cheung; Raymond Wai-Yin Sun; Yuan-Lan Shu; Yun-Wah Lam; Chi-Ming Che; Tai-Chu Lau

doi:10.1039/c0cc04515b

Osmium(vi) complexes as a new class of potential anti-cancer agents

Wen-Xiu Ni, Wai-Lun Man, Myra Ting-Wai Cheung, Raymond Wai-Yin Sun, Yuan-Lan Shu, Yun-Wah Lam, Chi-Ming Che, Tai-Chu Lau

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

46 Citations (Scopus)

Abstract

A nitridoosmium(vi) complex [Os^VI(N)(sap)(OH₂)Cl] (H₂sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. © 2011 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	2140-2142
Journal	Chemical Communications
Volume	47
Issue number	7
DOIs	https://doi.org/10.1039/c0cc04515b
Publication status	Published - 21 Feb 2011

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title = "Osmium(vi) complexes as a new class of potential anti-cancer agents",

abstract = "A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. {\textcopyright} 2011 The Royal Society of Chemistry.",

author = "Wen-Xiu Ni and Wai-Lun Man and Cheung, {Myra Ting-Wai} and Sun, {Raymond Wai-Yin} and Yuan-Lan Shu and Yun-Wah Lam and Chi-Ming Che and Tai-Chu Lau",

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T1 - Osmium(vi) complexes as a new class of potential anti-cancer agents

AU - Ni, Wen-Xiu

AU - Man, Wai-Lun

AU - Cheung, Myra Ting-Wai

AU - Sun, Raymond Wai-Yin

AU - Shu, Yuan-Lan

AU - Lam, Yun-Wah

AU - Che, Chi-Ming

AU - Lau, Tai-Chu

PY - 2011/2/21

Y1 - 2011/2/21

N2 - A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. © 2011 The Royal Society of Chemistry.

AB - A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. © 2011 The Royal Society of Chemistry.

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-79551475837&origin=recordpage

U2 - 10.1039/c0cc04515b

DO - 10.1039/c0cc04515b

M3 - RGC 21 - Publication in refereed journal

C2 - 21203649

SN - 0009-241X

VL - 47

SP - 2140

EP - 2142

JO - Chemical Communications

JF - Chemical Communications

IS - 7

ER -

Osmium(vi) complexes as a new class of potential anti-cancer agents

Abstract

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