Origin and evolution of new exons in rodents

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Wen Wang
  • Hongkun Zheng
  • Shuang Yang
  • Haijing Yu
  • Huifeng Jiang
  • Jianning Su
  • Lei Yang
  • Jianguo Zhang
  • Jason McDermott
  • Ram Samudrala
  • Jian Wang
  • Huanming Yang
  • Jun Yu
  • Karsten Kristiansen
  • Gane Ka-Shu Wong
  • Jun Wang

Detail(s)

Original languageEnglish
Pages (from-to)1258-1264
Journal / PublicationGenome Research
Volume15
Issue number9
Online publishedAug 2005
Publication statusPublished - Sept 2005
Externally publishedYes

Abstract

Gene number difference among organisms demonstrates that new gene origination is a fundamental biological process in evolution. Exon shuffling has been universally observed in the formation of new genes. Yet to be learned are the ways new exons originate and evolve, and how often new exons appear. To address these questions, we identified 2695 newly evolved exons in the mouse and rat by comparing the expressed sequences of 12,419 orthologous genes between human and mouse, using 743,856 pig ESTs as the outgroup. The new exon origination rate is about 2.71 × 10-3 per gene per million years. These new exons have markedly accelerated rates both of nonsynonymous substitutions and of insertions/deletions (indels). A much higher proportion of new exons have Ka/Ks ratios >1 (where Ka is the nonsynonymous substitution rate and Ks is the synonymous substitution rate) than do the old exons shared by human and mouse, implying a role of positive selection in the rapid evolution. The majority of these new exons have sequences unique in the genome, suggesting that most new exons might originate through "exonization" of intronic sequences. Most of the new exons appear to be alternative exons that are expressed at low levels.

Citation Format(s)

Origin and evolution of new exons in rodents. / Wang, Wen; Zheng, Hongkun; Yang, Shuang et al.
In: Genome Research, Vol. 15, No. 9, 09.2005, p. 1258-1264.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review