Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography

Lawrence Coles; Domenico Ventrella; Alejandro Carnicer-Lombarte; Alberto Elmi; Joe G. Troughton; Massimo Mariello; Salim El Hadwe; Ben J. Woodington; Maria L. Bacci; George G. Malliaras; Damiano G. Barone; Christopher M. Proctor

doi:10.1038/s41467-024-50597-2

Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography

Lawrence Coles, Domenico Ventrella, Alejandro Carnicer-Lombarte, Alberto Elmi, Joe G. Troughton, Massimo Mariello, Salim El Hadwe, Ben J. Woodington, Maria L. Bacci, George G. Malliaras, Damiano G. Barone, Christopher M. Proctor^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

29 Citations (Scopus)

Abstract

Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques. © The Author(s) 2024.

Original language	English
Article number	6290
Number of pages	11
Journal	Nature Communications
Volume	15
Online published	26 Jul 2024
DOIs	https://doi.org/10.1038/s41467-024-50597-2
Publication status	Published - 2024
Externally published	Yes

Funding

L.C. acknowledges funding from the U.K. Engineering and Physical Sciences Research Council Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future (EP/S023046/1). M.L.B. and D.V. acknowledge funding from the University of Bologna (RFO programme 2021\u20132022). A.C.L. acknowledges funding from the University of Cambridge Borysiewicz Fellowship program. B.J.W. acknowledges funding from the Engineering and Physical Sciences Research Council Centre for Doctoral Training in Sensor Technologies and Applications (EP/L015889/1). J.G.T. is supported by the National Institute for Health Research Invention for Innovation award (NIHR203355). M.M. is supported by the Biotechnology and Biological Sciences Research Council (BB/T009314/1). D.G.B. is supported by Health Education England and the National Institute for Health Research HEE/NIHR ICA Program Clinical Lectureship (CL-2019-14-004). S.E.H. acknowledge funding from the National Institute of Health Research (NIHR) (G112655) and is the Laureate of the Helaers Research Prize for Neurosurgery. C.M.P. acknowledges funding from the U.K. Engineering and Physical Sciences Research Council IAA award, and the Biotechnology and Biological Sciences Research Council David Phillips Fellowship (BB/T009314/1). The devices were built in the laboratory for prototyping soft neuroprosthetic technologies, funded by the Sir Jules Thorn charitable trust (233838).

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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Coles, L., Ventrella, D., Carnicer-Lombarte, A., Elmi, A., Troughton, J. G., Mariello, M., El Hadwe, S., Woodington, B. J., Bacci, M. L., Malliaras, G. G., Barone, D. G., & Proctor, C. M. (2024). Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography. Nature Communications, 15, Article 6290. https://doi.org/10.1038/s41467-024-50597-2

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title = "Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography",

abstract = "Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques. {\textcopyright} The Author(s) 2024.",

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AU - Mariello, Massimo

AU - El Hadwe, Salim

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AU - Barone, Damiano G.

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AB - Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques. © The Author(s) 2024.

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Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography

Abstract

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