Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 12 - Chapter in an edited book (Author) › peer-review

1 Scopus Citations
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Author(s)

  • Artem Osypenko
  • Adnan Ashraf
  • Valentyn Pozhydaiev
  • Maria V. Babak
  • Muhammad Hanif

Related Research Unit(s)

Detail(s)

Original languageEnglish
Title of host publicationComprehensive Organometallic Chemistry IV
EditorsGerard Parkin, Karsten Meyer, Karsten Meyer, Lena J. Daumann, Eszter Boros
Place of PublicationAmsterdam
PublisherElsevier
Pages206-225
Volume15
ISBN (electronic)9780323913508
ISBN (print)9780128202067
Publication statusPublished - 2022

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-85175392561&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(fbd0ea99-a9a1-4e2f-aee6-bfb264bd1dec).html

Abstract

Bioorganometallic chemistry is a multidisciplinary field that focuses on the biological properties of metal complexes with at least one metal-carbon bond. More recently, organometallic compounds have emerged as promising alternative chemotherapeutics. In particular, organometallic Ru and Os complexes have shown potent anticancer activity in vitro and in vivo. They exhibit modes of action that are different from clinical platinum drugs. In addition to DNA targeting, Ru and Os organometallic compounds exert their antitumor-effects through redox activation or targeting proteins and enzymes. This article highlights the leading classes of bioactive organometallics compounds based on Ru and Os metal centers. © 2022 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Bioorganometallic chemistry, Carbene ligands, Cyclometalated, Half-sandwich compounds, Metal clusters, Metal complexes, Metallodrugs, Organometallics, Osmium, Phosphine ligands, Ruthenium

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Publication fingerprints text

100
Ruthenium Chemistry
100
Osmium Chemistry
100
Organometallic Chem... Chemistry
100
Organometallic Comp... Chemistry
100
Organometallics Chemical Engineering
33
Metallocene Chemistry
33
Biological Property Chemistry
33
Antitumor Chemistry
33
Bioorganometallic C... Chemistry
33
DNA Chemistry
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Citation Format(s)

[ RIS ] [ BibTeX ]
Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes. / Osypenko, Artem; Ashraf, Adnan; Pozhydaiev, Valentyn et al.
Comprehensive Organometallic Chemistry IV. ed. / Gerard Parkin; Karsten Meyer; Karsten Meyer; Lena J. Daumann; Eszter Boros. Vol. 15 Amsterdam: Elsevier, 2022. p. 206-225.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 12 - Chapter in an edited book (Author) › peer-review