Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)12_Chapter in an edited book (Author)peer-review

1 Scopus Citations
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Author(s)

  • Artem Osypenko
  • Adnan Ashraf
  • Valentyn Pozhydaiev
  • Maria V. Babak
  • Muhammad Hanif

Related Research Unit(s)

Detail(s)

Original languageEnglish
Title of host publicationComprehensive Organometallic Chemistry IV
EditorsGerard Parkin, Karsten Meyer, Karsten Meyer, Lena J. Daumann, Eszter Boros
Place of PublicationAmsterdam
PublisherElsevier
Pages206-225
Volume15
ISBN (Print)9780323913508
Publication statusPublished - 2022

Abstract

Bioorganometallic chemistry is a multidisciplinary field that focuses on the biological properties of metal complexes with at least one metal-carbon bond. More recently, organometallic compounds have emerged as promising alternative chemotherapeutics. In particular, organometallic Ru and Os complexes have shown potent anticancer activity in vitro and in vivo. They exhibit modes of action that are different from clinical platinum drugs. In addition to DNA targeting, Ru and Os organometallic compounds exert their antitumor-effects through redox activation or targeting proteins and enzymes. This article highlights the leading classes of bioactive organometallics compounds based on Ru and Os metal centers. © 2022 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Bioorganometallic chemistry, Carbene ligands, Cyclometalated, Half-sandwich compounds, Metal clusters, Metal complexes, Metallodrugs, Organometallics, Osmium, Phosphine ligands, Ruthenium

Citation Format(s)

Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes. / Osypenko, Artem; Ashraf, Adnan; Pozhydaiev, Valentyn et al.
Comprehensive Organometallic Chemistry IV. ed. / Gerard Parkin; Karsten Meyer; Karsten Meyer; Lena J. Daumann; Eszter Boros. Vol. 15 Amsterdam: Elsevier, 2022. p. 206-225.

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)12_Chapter in an edited book (Author)peer-review