Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes

Artem Osypenko; Adnan Ashraf; Valentyn Pozhydaiev; Maria V. Babak; Muhammad Hanif

doi:10.1016/B978-0-12-820206-7.00045-7

Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes

Artem Osypenko, Adnan Ashraf, Valentyn Pozhydaiev, Maria V. Babak, Muhammad Hanif

Department of Chemistry

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 12 - Chapter in an edited book (Author) › peer-review

1 Citation (Scopus)

Abstract

Bioorganometallic chemistry is a multidisciplinary field that focuses on the biological properties of metal complexes with at least one metal-carbon bond. More recently, organometallic compounds have emerged as promising alternative chemotherapeutics. In particular, organometallic Ru and Os complexes have shown potent anticancer activity in vitro and in vivo. They exhibit modes of action that are different from clinical platinum drugs. In addition to DNA targeting, Ru and Os organometallic compounds exert their antitumor-effects through redox activation or targeting proteins and enzymes. This article highlights the leading classes of bioactive organometallics compounds based on Ru and Os metal centers. © 2022 Elsevier Ltd. All rights reserved.

Original language	English
Title of host publication	Comprehensive Organometallic Chemistry IV
Editors	Gerard Parkin, Karsten Meyer, Karsten Meyer, Lena J. Daumann, Eszter Boros
Place of Publication	Amsterdam
Publisher	Elsevier
Pages	206-225
Volume	15
ISBN (Electronic)	9780323913508
ISBN (Print)	9780128202067
DOIs	https://doi.org/10.1016/B978-0-12-820206-7.00045-7
Publication status	Published - 2022

Research Keywords

Bioorganometallic chemistry
Carbene ligands
Cyclometalated
Half-sandwich compounds
Metal clusters
Metal complexes
Metallodrugs
Organometallics
Osmium
Phosphine ligands
Ruthenium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Bioorganometallic chemistry is a multidisciplinary field that focuses on the biological properties of metal complexes with at least one metal-carbon bond. More recently, organometallic compounds have emerged as promising alternative chemotherapeutics. In particular, organometallic Ru and Os complexes have shown potent anticancer activity in vitro and in vivo. They exhibit modes of action that are different from clinical platinum drugs. In addition to DNA targeting, Ru and Os organometallic compounds exert their antitumor-effects through redox activation or targeting proteins and enzymes. This article highlights the leading classes of bioactive organometallics compounds based on Ru and Os metal centers. {\textcopyright} 2022 Elsevier Ltd. All rights reserved.",

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Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes. / Osypenko, Artem; Ashraf, Adnan; Pozhydaiev, Valentyn et al.
Comprehensive Organometallic Chemistry IV. ed. / Gerard Parkin; Karsten Meyer; Karsten Meyer; Lena J. Daumann; Eszter Boros. Vol. 15 Amsterdam: Elsevier, 2022. p. 206-225.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 12 - Chapter in an edited book (Author) › peer-review

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AU - Ashraf, Adnan

AU - Pozhydaiev, Valentyn

AU - Babak, Maria V.

AU - Hanif, Muhammad

PY - 2022

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AB - Bioorganometallic chemistry is a multidisciplinary field that focuses on the biological properties of metal complexes with at least one metal-carbon bond. More recently, organometallic compounds have emerged as promising alternative chemotherapeutics. In particular, organometallic Ru and Os complexes have shown potent anticancer activity in vitro and in vivo. They exhibit modes of action that are different from clinical platinum drugs. In addition to DNA targeting, Ru and Os organometallic compounds exert their antitumor-effects through redox activation or targeting proteins and enzymes. This article highlights the leading classes of bioactive organometallics compounds based on Ru and Os metal centers. © 2022 Elsevier Ltd. All rights reserved.

KW - Bioorganometallic chemistry

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ER -

Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes

Abstract

Research Keywords

UN SDGs

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