Organobromine compound profiling in human adipose : Assessment of sources of bromophenol

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

21 Scopus Citations
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Author(s)

  • Shixiong Gao
  • Yi Wan
  • Guomao Zheng
  • Kai Luo
  • Kurunthachalam Kannan
  • And 3 others
  • John P. Giesy
  • Michael H.W. Lam
  • Jianying Hu

Detail(s)

Original languageEnglish
Pages (from-to)81-89
Journal / PublicationEnvironmental Pollution
Volume204
Publication statusPublished - 1 Sept 2015

Abstract

Bromophenols (BRPs) have been widely detected in human tissues, however, relative proportions from natural products and/or anthropogenic flame retardants are not clear. 21 polybrominated diphenyl ethers (PBDEs), 15 MeO/OH-PBDEs, and 10 BRPs were simultaneously quantified in adipose collected from people from New York City, USA. An in vitro assay utilizing human liver microsomes was performed for detected predominant organobromine. High concentrations of 2,4,6-triBRP and PBDEs were observed, and extremely low concentrations of naturally occurring MeO/OH-PBDEs were detected. Similar biotransformatioin rates of BRPs and MeO/OH-PBDEs indicated that the relative high concentration of 2,4,6-triBRP in humans was not of natural origin. Significant correlation observed between concentrations of 2,4,6-triBRP and BDE-209 suggested that the two chemicals may share a common source. Both 2,4,6-triBRP and BDE-209 were detected in commercial ABS resins, suggesting that plastic products made from ABS resins could be potential sources of co-exposure of the two compounds for humans.

Research Area(s)

  • Adipose tissue, Anthropogenic compounds, BRPs, Co-exposure, GC-NCI-MS, Organobromine compounds

Citation Format(s)

Organobromine compound profiling in human adipose: Assessment of sources of bromophenol. / Gao, Shixiong; Wan, Yi; Zheng, Guomao et al.
In: Environmental Pollution, Vol. 204, 01.09.2015, p. 81-89.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review