Organic semiconducting polymer amphiphile for near-infrared-II light-triggered phototheranostics

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

6 Scopus Citations
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Author(s)

  • Chao Yin
  • Boguang Yang
  • Xiaoyu Chen
  • Pengchao Zhao
  • Shengliang Li
  • Rui Li
  • Liming Bian

Detail(s)

Original languageEnglish
Article number119684
Journal / PublicationBiomaterials
Volume232
Online published13 Dec 2019
Publication statusPublished - Feb 2020

Abstract

Development of near-infrared-II (NIR-II) light responsive nano-agents with high photothermal stability, high photothermal conversion efficiency (PCE), and excellent biocompatibility for photoacoustic (PA) imaging-guided photothermal therapy (PTT) is of tremendous significance. In spite of the superiority of organic semiconducting polymer nanoparticles (OSPNs) in PA imaging-guided PTT, the limited absorption in the first NIR (NIR-I) window and metastable nanostructure of OSPNs resulting from commonly used preparation methods based on nanoprecipitation or reprecipitation compromise their in vivo phototheranostic performance. Herein we design and synthesize a novel NIR-II absorbing organic semiconducting polymer amphiphile (OSPA) to enhance the structural stability of OSPNs. With prominent optical properties, low toxicity, and a suitable size, OSPA not only efficiently labels and kills cancer cells under NIR-II irradiation but also accumulates at the tumor of living mice upon intravenous injection, allowing efficient NIR-II light-triggered phototheranostics toward tumor. The developed OSPA has promising potential for fabricating multifunctional nanoplatforms to enable multimodal theranostics.

Research Area(s)

  • Amphiphile, Photoacoustic imaging, Photothermal therapy, Second near-infrared window, Semiconducting polymer

Citation Format(s)

Organic semiconducting polymer amphiphile for near-infrared-II light-triggered phototheranostics. / Yin, Chao; Li, Xiaozhen; Wen, Guohua; Yang, Boguang; Zhang, Yachao; Chen, Xiaoyu; Zhao, Pengchao; Li, Shengliang; Li, Rui; Wang, Lidai; Lee, Chun-Sing; Bian, Liming.

In: Biomaterials, Vol. 232, 119684, 02.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal