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Optimal decorrelated score subsampling for Cox regression with massive survival data

  • Yujing Shao
  • , Zhaohan Hou
  • , Lei Wang*
  • , Heng Lian
  • *Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

Abstract

This paper investigates optimal subsampling strategies for the preconceived low-dimensional parameters of main interest in the presence of the nuisance parameters for Cox regression with massive survival data. A general subsampling decorrelated score function based on the log-partial likelihood is constructed to reduce the influence of the less accurate nuisance parameter estimation with a possibly slow convergence rate. The consistency and asymptotic normality of the resultant subsample estimators are established. We derive unified optimal subsampling probabilities based on A- and L-optimality criteria. A two-step algorithm is further proposed to implement practically, and the asymptotic properties of the resultant estimators are also given. The satisfactory performance of our proposed subsample estimators is demonstrated by simulation results and an airline dataset. © 2025 Elsevier B.V.
Original languageEnglish
Article number130090
JournalNeurocomputing
Volume638
Online published5 Apr 2025
DOIs
Publication statusPublished - 14 Jul 2025

Funding

The authors would like to thank the Editor, an Associate Editor and two anonymous referees for their constructive comments that improved the paper\u2019s quality. Our research was supported by the National Natural Science Foundation of China (12271272). All authors contributed to this work equally.

Research Keywords

  • Censoring
  • Decorrelated score subsampling
  • High-dimensional inference
  • Survival analysis

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