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OPTICALLY-INDUCED CELL FUSION ON MICROFLUIDIC CHIP UTILIZING LOCALLY ENHANCED ELECTRIC FIELD

  • P. F. Yang
  • , C. H. Wang
  • , G. B. Lee*
  • *Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review

Abstract

This work reports a new approach called optically-induced cell fusion (OICF) which integrates cell-pairing microstructures and an optically-induced system to achieve cell fusion with high yields and efficiency. It is the first time in literature that cell-pairing SU8 microstructures were combined with optically-induced "virtual" electrodes to form the OICF system such that precise cell-pairing and high-yield cell fusion could be achieved. Experimental results showed that HeLa cells and MCF-7 cells could be successfully fused using this new approach. Furthermore, the new method allows one to selectively fuse cells by using addressable light patterns. It is therefore promising for further biomedical applications.
Original languageEnglish
Title of host publication2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PublisherIEEE
Pages269-272
ISBN (Electronic)9781479989553
DOIs
Publication statusPublished - 2015
Externally publishedYes
Event18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
Duration: 21 Jun 201525 Jun 2015

Publication series

NameInternational Conference on Solid State Sensors and Actuators (TRANSDUCERS)
PublisherIEEE
ISSN (Print)2159-547X
ISSN (Electronic)2164-1641

Conference

Conference18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PlaceUnited States
CityAnchorage
Period21/06/1525/06/15

Research Keywords

  • Cell fusion
  • Microfluidics
  • Optically-induced system
  • Virtual electrode

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