Optical focusing in scattering media with photoacoustic wavefront shaping (PAWS)

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review

6 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8943
ISBN (Print)9780819498564
Publication statusPublished - 2014
Externally publishedYes

Publication series

Name
Volume8943
ISSN (Print)1605-7422

Conference

TitlePhotons Plus Ultrasound: Imaging and Sensing 2014
PlaceUnited States
CitySan Francisco
Period2 - 5 February 2014

Abstract

Controllable light delivery to the region of interest is essential to biomedical optical imaging methods like photoacoustic microscopy. It is, however, challenging beyond superficial depths in biological tissue (∼1 mm beneath human skin) due to the strong scattering of light that scrambles the photon propagation paths. Recently, optical wavefront shaping has been proposed to modulate the incident light wavefront to compensate for the scattering-induced phase distortions, and consequentially, convey light optimally to a desired location behind or inside turbid media. To reach an optimum wavefront, a searching algorithm is usually required to optimize a feedback signal. In this work, we present our latest explorations, which use photoacoustic signals as the feedback to remotely and non-invasively guide the wavefront shaping process. Our method does not require direct optical access to the target region or the invasive embedding of fluorescence probes inside turbid media. Experimentally, we have demonstrated that diffuse light can be converged to the ultrasound focus by maximizing the amplitude of photoacoustic emissions from the intended absorbing site. Moreover, we show that wavefront-shaped light focusing can enhance existing optical imaging modalities like photoacoustic microscopy, in regard to signal-to-noise ratio, imaging depth, and potentially, resolution. © 2014 SPIE.

Research Area(s)

  • Grueneisen memory effect, Light scattering, Nonlinear photoacoustic signal, Optical focusing, Optical speckle, Photoacoustic imaging, Spatial light modulator, Wavefront shaping

Citation Format(s)

Optical focusing in scattering media with photoacoustic wavefront shaping (PAWS). / Lai, Puxiang; Tay, Jian Wei; Wang, Lidai et al.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8943 SPIE, 2014. 894318.

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review