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Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

  • W. Z. Song
  • , X. M. Zhang
  • , L. K. Chin
  • , C. S. Lim
  • , A. Q. Liu
  • , P. H. Yap
  • , H. M. Hosseini

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening. © 2006 Society for Chemistry and Micro-Nano Systems.
Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherJapan Academic Association Inc
Pages528-530
Publication statusPublished - 2006
Externally publishedYes
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: 5 Nov 2006 → 9 Nov 2006

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
PlaceJapan
CityTokyo
Period5/11/06 → 9/11/06

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

  • Fabry-Perot cavity
  • Living cells
  • Optofluidic microchip
  • Refractive index

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