One-step, room temperature, colorimetric detection of mercury (Hg 2+) using DNA/nanoparticle conjugates

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

692 Scopus Citations
View graph of relations

Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)3244-3245
Journal / PublicationJournal of the American Chemical Society
Volume130
Issue number11
Publication statusPublished - 19 Mar 2008
Externally publishedYes

Abstract

Introduction of Hg2+ into an aqueous solution containing oligonucleotide-tethered gold nanoparticle probes and a linker oligonucleotide with a number of thymine-thymine (T-T) mismatches results in the formation of particle aggregates at room temperature with a concomitant colorimetric response. The high selectivity of this detection system is attributed to Hg2+-mediated formation of T-Hg2+-T base pairs as evidenced by an increase in a sharp melting temperature. Copyright © 2008 American Chemical Society.