One-pot synthesis of albumin-gadolinium stabilized polypyrrole nanotheranostic agent for magnetic resonance imaging guided photothermal therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Zhe Yang
  • Wenshan He
  • Hongyi Zheng
  • Jielin Wei
  • Pei Liu
  • Wei Zhu
  • Leping Lin
  • Changfeng Yi
  • Zushun Xu
  • Jinghua Ren

Detail(s)

Original languageEnglish
Pages (from-to)1-10
Journal / PublicationBiomaterials
Volume161
Online published19 Jan 2018
Publication statusPublished - Apr 2018
Externally publishedYes

Abstract

Theranostic agents with perfect properties are needed urgently for the development of imaging guided photothermal therapy (PTT). In this work, Gd-integrated polypyrrole nanotheranostic agent (PPy@BSA-Gd) was successfully built through selecting bovine serum albumin (BSA) as both stabilizers for polymerization and biomimetic mineralization in "one pot". The obtained PPy@BSA-Gd possessed high stability and excellent photothermal property. Besides, relevant cellular assays indicated that PPy@BSA-Gd had fantastic cytocompatibility which could be further internalized by cancer cells. Due to their high longitudinal relaxivity value (r1 = 10.203 mM-1s-1), PPy@BSA-Gd could serve as considerable probe for T1-weighted magnetic resonance imaging (MRI). After tail vein injection of PPy@BSA-Gd, the MR signal of tumor section exhibited a time-dependent increase, indicating effective tumor accumulation of PPy@BSA-Gd. Notably, when exposed to 808 nm laser, the tumor growth of PPy@BSA-Gd treated mice could be inhibited by photothermal ablation successfully. All the results demonstrated the well-designed PPy@BSA-Gd have the potential for tumor diagnose and photothermal therapy.

Research Area(s)

  • Polypyrrole, Photothermal therapy, Biomimetic mineralization, MRI

Citation Format(s)

One-pot synthesis of albumin-gadolinium stabilized polypyrrole nanotheranostic agent for magnetic resonance imaging guided photothermal therapy. / Yang, Zhe; He, Wenshan; Zheng, Hongyi; Wei, Jielin; Liu, Pei; Zhu, Wei; Lin, Leping; Zhang, Li; Yi, Changfeng; Xu, Zushun; Ren, Jinghua.

In: Biomaterials, Vol. 161, 04.2018, p. 1-10.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal