One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
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Detail(s)
Original language | English |
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Pages (from-to) | 11948-11951 |
Journal / Publication | Chemical Communications |
Volume | 57 |
Issue number | 90 |
Online published | 21 Oct 2021 |
Publication status | Published - 21 Nov 2021 |
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DOI | DOI |
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Attachment(s) | Documents
Publisher's Copyright Statement
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85119833370&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(848a4ae7-9ef0-44a1-b6b1-58df4811461b).html |
Abstract
A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.
Research Area(s)
- DENDRITIC POLYGLYCEROL SULFATES, MECHANISMS, ENTRY
Citation Format(s)
One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors. / Ahmadi, Vahid; Nie, Chuanxiong; Mohammadifar, Ehsan et al.
In: Chemical Communications, Vol. 57, No. 90, 21.11.2021, p. 11948-11951.
In: Chemical Communications, Vol. 57, No. 90, 21.11.2021, p. 11948-11951.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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