One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Vahid Ahmadi
  • Chuanxiong Nie
  • Ehsan Mohammadifar
  • Katharina Achazi
  • Stefanie Wedepohl
  • Yannic Kerkhoff
  • Stephan Block
  • Rainer Haag

Detail(s)

Original languageEnglish
Pages (from-to)11948-11951
Journal / PublicationChemical Communications
Volume57
Issue number90
Online published21 Oct 2021
Publication statusPublished - 21 Nov 2021

Abstract

A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.

Research Area(s)

  • DENDRITIC POLYGLYCEROL SULFATES, MECHANISMS, ENTRY

Citation Format(s)

One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors. / Ahmadi, Vahid; Nie, Chuanxiong; Mohammadifar, Ehsan; Achazi, Katharina; Wedepohl, Stefanie; Kerkhoff, Yannic; Block, Stephan; Osterrieder, Klaus; Haag, Rainer.

In: Chemical Communications, Vol. 57, No. 90, 21.11.2021, p. 11948-11951.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review