One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

Mingyue Cui; Christian Wiraja; Lim Wei Qi; Sharon Chew Wan Ting; Deblin Jana; Mengjia Zheng; Xiao Hu; Chenjie Xu

doi:10.1007/s12274-020-2775-z

One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

Mingyue Cui, Christian Wiraja, Lim Wei Qi, Sharon Chew Wan Ting, Deblin Jana, Mengjia Zheng, Xiao Hu, Chenjie Xu^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

5 Citations (Scopus)

Abstract

Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility, controllable morphology and so on. They can be used both as the drug carrier and imaging vehicle. Here, an aminated ultra-small silica nanoparticle based system is developed with various functionalities. Multiple molecules including fluorophore, folic acid, and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.

Original language	English
Pages (from-to)	1592-1596
Journal	Nano Research
Volume	13
Issue number	6
Online published	2 May 2020
DOIs	https://doi.org/10.1007/s12274-020-2775-z
Publication status	Published - Jun 2020

Research Keywords

silica nanoparticles
one-step synthesis
surface modification
bacterial & cell labelling

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AU - Wiraja, Christian

AU - Qi, Lim Wei

AU - Ting, Sharon Chew Wan

AU - Jana, Deblin

AU - Zheng, Mengjia

AU - Hu, Xiao

AU - Xu, Chenjie

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AB - Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility, controllable morphology and so on. They can be used both as the drug carrier and imaging vehicle. Here, an aminated ultra-small silica nanoparticle based system is developed with various functionalities. Multiple molecules including fluorophore, folic acid, and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.

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KW - surface modification

KW - bacterial & cell labelling

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One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

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Research Keywords

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