Projects per year
Abstract
The combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT) have attracted a great deal of interest, but tumor hypoxia and glutathione (GSH) overproduction still limit their further applications. Herein, an intelligent reactive oxygen species (ROS) nanogenerator Ce6/GOx@ZIF-8/PDA@MnO2 (denoted as CGZPM; Ce6, GOx, ZIF-8, PDA, MnO2 are chlorin e6, glucose oxidase, zeolitic imidazolate framework-8, polydopamine and manganese dioxide respectively) with O2-generating and GSH-/glucose-depleting abilities was constructed by a facile and green one-pot method. After intake by tumor cells, the outer MnO2 was rapidly degraded by the acidic pH, and the overexpression of hydrogen peroxide (H2O2) and GSH with abundant Mn2+ and O2 produced would eventually achieve multifunctionality. The Mn2+ acted as an ideal Fenton-like agent and magnetic resonance (MR) imaging contrast agent, while the O2 promoted the PDT via hypoxia relief and facilitated the intratumoral glucose oxidation by GOx for starvation therapy (ST). Benefiting from the GOx-based glycolysis process, sufficient H2O2 was generated to improve the CDT efficacy through Mn2+-mediated Fenton-like reaction. Notably, MnO2 and PDA could decrease the tumor antioxidant activity by consuming GSH, resulting in remarkably enhanced PDT/CDT. Such a novel cascade bioreactor with tumor microenvironment (TME)-modulating capability opens new opportunities for ROS-based and combinational treatment paradigms.
| Original language | English |
|---|---|
| Pages (from-to) | 543-555 |
| Journal | Journal of Colloid and Interface Science |
| Volume | 599 |
| Online published | 2 Apr 2021 |
| DOIs | |
| Publication status | Published - Oct 2021 |
Research Keywords
- Photodynamic therapy
- Chemodynamic therapy
- Glutathione-depleting
- Magnetic resonance imaging
- Starvation therapy
RGC Funding Information
- RGC-funded
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Dive into the research topics of 'One-pot synthesis of a self-reinforcing cascade bioreactor for combined photodynamic/chemodynamic/starvation therapy'. Together they form a unique fingerprint.Projects
- 3 Finished
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GRF: Constructing Metalated Heterocycles via Alkyne Cycloisomerization: Mechanism and Application
WONG, C. Y. A. (Principal Investigator / Project Coordinator)
1/01/21 → 12/06/25
Project: Research
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GRF: Rational Design of Photoresponsive Anti-Cancer Drug Delivery Nanoparticles
WONG, C. Y. A. (Principal Investigator / Project Coordinator) & LEUNG, D.C.-H. (Co-Investigator)
1/01/18 → 6/12/21
Project: Research
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TBRS: A Compact System for Terahertz Imaging and Spectroscopy
CHAN, C. H. (Principal Investigator / Project Coordinator), LO, K. W. K. (Co-Principal Investigator), LUK, K. M. (Co-Principal Investigator), PUN, Y. B. E. (Co-Principal Investigator), Pang, S. (Co-Principal Investigator), SHAW, J. (Co-Principal Investigator), VELLAISAMY, A. L. R. (Co-Principal Investigator), CHAN, S. C. (Co-Investigator), DECROZE, C. (Co-Investigator), HO, J. C. Y. (Co-Investigator), JARRAHI, M. (Co-Investigator), LAM, Y. W. (Co-Investigator), LEE, E.-Y. J. (Co-Investigator), LEE, N. P. Y. (Co-Investigator), LEUNG, K. W. (Co-Investigator), LIU, H. (Co-Investigator), QU, S. (Co-Investigator), RENAUD, C. (Co-Investigator), Tong, K. (Co-Investigator), WANG, C. (Co-Investigator), WONG, H. (Co-Investigator), WONG, C. Y. A. (Co-Investigator), WONG, M. H. A. (Co-Investigator) & Wong, K. K. Y. (Co-Investigator)
1/01/17 → 30/06/23
Project: Research