One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

Vahid Ahmadi; Chuanxiong Nie; Ehsan Mohammadifar; Katharina Achazi; Stefanie Wedepohl; Yannic Kerkhoff; Stephan Block; Klaus Osterrieder; Rainer Haag

doi:10.1039/d1cc04703e

One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

Vahid Ahmadi^*
, Chuanxiong Nie
, Ehsan Mohammadifar
, Katharina Achazi
, Stefanie Wedepohl
, Yannic Kerkhoff
, Stephan Block
, Klaus Osterrieder
, Rainer Haag^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

20 Citations (Scopus)

48 Downloads (CityUHK Scholars)

Abstract

A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.

Original language	English
Pages (from-to)	11948-11951
Journal	Chemical Communications
Volume	57
Issue number	90
Online published	21 Oct 2021
DOIs	https://doi.org/10.1039/d1cc04703e
Publication status	Published - 21 Nov 2021

Research Keywords

DENDRITIC POLYGLYCEROL SULFATES
MECHANISMS
ENTRY

Publisher's Copyright Statement

This full text is made available under CC-BY-NC 3.0. https://creativecommons.org/licenses/by-nc/3.0/

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abstract = "A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.",

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AU - Ahmadi, Vahid

AU - Nie, Chuanxiong

AU - Mohammadifar, Ehsan

AU - Achazi, Katharina

AU - Wedepohl, Stefanie

AU - Kerkhoff, Yannic

AU - Block, Stephan

AU - Osterrieder, Klaus

AU - Haag, Rainer

PY - 2021/11/21

Y1 - 2021/11/21

N2 - A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.

AB - A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.

KW - DENDRITIC POLYGLYCEROL SULFATES

KW - MECHANISMS

KW - ENTRY

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U2 - 10.1039/d1cc04703e

DO - 10.1039/d1cc04703e

M3 - RGC 21 - Publication in refereed journal

SN - 1359-7345

VL - 57

SP - 11948

EP - 11951

JO - Chemical Communications

JF - Chemical Communications

IS - 90

ER -

One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

Abstract

Research Keywords

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