Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Esther H. Chang
  • Kathleen F. Pirollo
  • Zhi Qiang Zou
  • Hon-Yeung Cheung
  • Elsbeth Lee Lawler
  • And 5 others
  • Rosa Garner
  • Elizabeth White
  • Wendy B. Bernstein
  • Joseph W. Fraumeni Jr.
  • William A. Blattner

Detail(s)

Original languageEnglish
Pages (from-to)1036-1039
Journal / PublicationScience
Volume237
Issue number4818
Publication statusPublished - 1987
Externally publishedYes

Abstract

Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.

Citation Format(s)

Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family. / Chang, Esther H.; Pirollo, Kathleen F.; Zou, Zhi Qiang; Cheung, Hon-Yeung; Lawler, Elsbeth Lee; Garner, Rosa; White, Elizabeth; Bernstein, Wendy B.; Fraumeni Jr., Joseph W.; Blattner, William A.

In: Science, Vol. 237, No. 4818, 1987, p. 1036-1039.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review