TY - JOUR
T1 - Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family
AU - Chang, Esther H.
AU - Pirollo, Kathleen F.
AU - Zou, Zhi Qiang
AU - Cheung, Hon-Yeung
AU - Lawler, Elsbeth Lee
AU - Garner, Rosa
AU - White, Elizabeth
AU - Bernstein, Wendy B.
AU - Fraumeni Jr., Joseph W.
AU - Blattner, William A.
PY - 1987/8/28
Y1 - 1987/8/28
N2 - Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.
AB - Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.
UR - http://www.scopus.com/inward/record.url?scp=0023219306&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-0023219306&origin=recordpage
U2 - 10.1126/science.3616624
DO - 10.1126/science.3616624
M3 - RGC 21 - Publication in refereed journal
C2 - 3616624
SN - 0036-8075
VL - 237
SP - 1036
EP - 1039
JO - Science
JF - Science
IS - 4818
ER -
