TY - JOUR
T1 - On statistical tests for homogeneity of two bivariate zero-inflated poisson populations
AU - Yuen, Hak-Keung
AU - Chow, Shein-Chung
AU - Tse, Siu-Keung
PY - 2015
Y1 - 2015
N2 - The problem of testing treatment difference in the occurrence of a study endpoint in a randomized parallel-group comparative clinical trial with repeated responses under the assumption that the responses follow a bivariate zero-inflated Poisson (ZIP) distribution is considered. Likelihood ratio test for homogeneity of two bivariate ZIP populations is derived. Approximate formula for sample size calculation is also obtained, which achieves a desired power for detecting a clinically meaningful difference under an alternative hypothesis. An example concerning the comparison of treatment effect in an addictive clinical trial in terms of the number of days of illicit drug use during a month is given for illustrative purposes.
AB - The problem of testing treatment difference in the occurrence of a study endpoint in a randomized parallel-group comparative clinical trial with repeated responses under the assumption that the responses follow a bivariate zero-inflated Poisson (ZIP) distribution is considered. Likelihood ratio test for homogeneity of two bivariate ZIP populations is derived. Approximate formula for sample size calculation is also obtained, which achieves a desired power for detecting a clinically meaningful difference under an alternative hypothesis. An example concerning the comparison of treatment effect in an addictive clinical trial in terms of the number of days of illicit drug use during a month is given for illustrative purposes.
KW - Erosion counts
KW - Likelihood ratio test
KW - Sample size calculation
KW - Zero-inflated poisson distribution
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U2 - 10.1080/10543406.2014.919934
DO - 10.1080/10543406.2014.919934
M3 - 21_Publication in refereed journal
C2 - 24837140
VL - 25
SP - 44
EP - 53
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
SN - 1054-3406
IS - 1
ER -