Omniphobic ZIF-8@Hydrogel Membrane by Microfluidic-Emulsion-Templating Method for Wound Healing

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xiaoxue Yao
  • Guoshuai Zhu
  • Jing Ma
  • Wenwen Chen
  • Zhou Liu
  • Tiantian Kong

Detail(s)

Original languageEnglish
Article number1909389
Journal / PublicationAdvanced Functional Materials
Volume30
Issue number13
Online published12 Feb 2020
Publication statusPublished - 24 Mar 2020
Externally publishedYes

Abstract

Bacterial adhesion and colonization can result in chronic non-healing wounds. Current hydrophilic wound dressings can release antibacterial agents into the wound exudate, but may result in overhydrated wounds, bacterial overgrowth, and even tissue maceration. Hydrophobic dressings are anti-fouling, though ineffective to encapsulate and release bactericidal agents. Combining the advantages of hydrophilic and hydrophobic dressings seems difficult, until the development of superwettability surfaces offers an opportunity for omniphobic dressings from intrinsic hydrophilic polymers. Herein, omniphobic porous hydrogel wound dressings loaded with a zinc imidazolate framework 8 (ZIF-8) are fabricated by a microfluidic-emulsion-templating method. The fabricated porous hydrogel membrane with its reentrant architecture is repellent to blood and body fluids, though intrinsically hydrophilic. This unique combination not only reduces the adhesion of harmful microbes, but also enables the encapsulation and release of antibacterial ingredients to wounded sites from hydrophilic polymer networks. As such, the omniphobic metal-organic frameworks (MOFs)@hydrogel porous wound dressing can inhibit bacteria invasion and enable the controlled release of the bactericidal, anti-inflammatory, and nontoxic zinc ions. Furthermore, in vivo study of infected full-thickness skin defect models demonstrates that the dressing also accelerates wound closure by promoting angiogenesis and collagen deposition. Therefore, the omniphobic MOFs@hydrogel porous wound dressings are potentially useful for clinical application.

Research Area(s)

  • antibacterial, microfluidics, MOFs, omniphobic, wound dressings

Citation Format(s)

Omniphobic ZIF-8@Hydrogel Membrane by Microfluidic-Emulsion-Templating Method for Wound Healing. / Yao, Xiaoxue; Zhu, Guoshuai; Zhu, Pingan; Ma, Jing; Chen, Wenwen; Liu, Zhou; Kong, Tiantian.

In: Advanced Functional Materials, Vol. 30, No. 13, 1909389, 24.03.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review