Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Long Wu
  • Xiaojun Liu
  • Ding Li

Detail(s)

Original languageEnglish
Pages (from-to)2235-2238
Journal / PublicationOrganic Letters
Volume10
Issue number11
Publication statusPublished - 5 Jun 2008

Abstract

(Chemical Equation Presented) Oct-2-yn-4-enoyl-CoA was found to be a multifunctional irreversible enzyme inhibitor in fatty acid oxidation mainly targeting mitochondrial trifunctional protein β-subunit. It can also inactivate enoyl-CoA hydratase 2 and medium-chain acyl-CoA dehydrogenase. This study increased our understanding for the effect of acetylenic acids on fatty acid oxidation. © 2008 American Chemical Society.

Citation Format(s)

Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation. / Wu, Long; Liu, Xiaojun; Li, Ding.

In: Organic Letters, Vol. 10, No. 11, 05.06.2008, p. 2235-2238.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal