Oct-2-en-4-ynoyl-CoA as a specific inhibitor of Acyl-CoA oxidase

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

3 Scopus Citations
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Author(s)

  • Jia Zeng
  • Long Wu
  • Xiaojian Zhang
  • Yuandong Liu
  • Guisheng Deng
  • And 1 others
  • Ding Li

Detail(s)

Original languageEnglish
Pages (from-to)4287-4290
Journal / PublicationOrganic Letters
Volume10
Issue number19
Publication statusPublished - 2008

Abstract

(Chemical Equation Presented) Oct-2-en-4-ynoyl-CoA was found to be a specific inhibitor of acyl-CoA oxidase in fatty acid oxidation in peroxisomes that has no inhibitory effect on acyl-CoA dehydrogenase in mitochondria. The inhibition reaction involves a nucleophilic attack of Glu421 to the δ carbon of the inhibitor. The result indicates that acyl-CoA oxidase and acyl-CoA dehydrogenase have certain differences in active-site structure, which makes it possible to control fatty acid oxidation selectively in either mitochondria or peroxisomes with different enzyme inhibitors. © 2008 American Chemical Society.

Citation Format(s)

Oct-2-en-4-ynoyl-CoA as a specific inhibitor of Acyl-CoA oxidase. / Zeng, Jia; Wu, Long; Zhang, Xiaojian; Liu, Yuandong; Deng, Guisheng; Li, Ding.

In: Organic Letters, Vol. 10, No. 19, 2008, p. 4287-4290.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal