Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation

Long Wu; Xiaojun Liu; Ding Li

doi:10.1021/ol800606r

Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation

Long Wu, Xiaojun Liu, Ding Li

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

7 Citations (Scopus)

Abstract

(Chemical Equation Presented) Oct-2-yn-4-enoyl-CoA was found to be a multifunctional irreversible enzyme inhibitor in fatty acid oxidation mainly targeting mitochondrial trifunctional protein β-subunit. It can also inactivate enoyl-CoA hydratase 2 and medium-chain acyl-CoA dehydrogenase. This study increased our understanding for the effect of acetylenic acids on fatty acid oxidation. © 2008 American Chemical Society.

Original language	English
Pages (from-to)	2235-2238
Journal	Organic Letters
Volume	10
Issue number	11
DOIs	https://doi.org/10.1021/ol800606r
Publication status	Published - 5 Jun 2008

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title = "Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation",

abstract = "(Chemical Equation Presented) Oct-2-yn-4-enoyl-CoA was found to be a multifunctional irreversible enzyme inhibitor in fatty acid oxidation mainly targeting mitochondrial trifunctional protein β-subunit. It can also inactivate enoyl-CoA hydratase 2 and medium-chain acyl-CoA dehydrogenase. This study increased our understanding for the effect of acetylenic acids on fatty acid oxidation. {\textcopyright} 2008 American Chemical Society.",

author = "Long Wu and Xiaojun Liu and Ding Li",

year = "2008",

month = jun,

day = "5",

doi = "10.1021/ol800606r",

language = "English",

volume = "10",

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journal = "Organic Letters",

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TY - JOUR

T1 - Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation

AU - Wu, Long

AU - Liu, Xiaojun

AU - Li, Ding

PY - 2008/6/5

Y1 - 2008/6/5

N2 - (Chemical Equation Presented) Oct-2-yn-4-enoyl-CoA was found to be a multifunctional irreversible enzyme inhibitor in fatty acid oxidation mainly targeting mitochondrial trifunctional protein β-subunit. It can also inactivate enoyl-CoA hydratase 2 and medium-chain acyl-CoA dehydrogenase. This study increased our understanding for the effect of acetylenic acids on fatty acid oxidation. © 2008 American Chemical Society.

AB - (Chemical Equation Presented) Oct-2-yn-4-enoyl-CoA was found to be a multifunctional irreversible enzyme inhibitor in fatty acid oxidation mainly targeting mitochondrial trifunctional protein β-subunit. It can also inactivate enoyl-CoA hydratase 2 and medium-chain acyl-CoA dehydrogenase. This study increased our understanding for the effect of acetylenic acids on fatty acid oxidation. © 2008 American Chemical Society.

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-52649084854&origin=recordpage

U2 - 10.1021/ol800606r

DO - 10.1021/ol800606r

M3 - RGC 21 - Publication in refereed journal

SN - 1523-7060

VL - 10

SP - 2235

EP - 2238

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation

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