Oct-2-en-4-ynoyl-CoA as a specific inhibitor of Acyl-CoA oxidase

Jia Zeng; Long Wu; Xiaojian Zhang; Yuandong Liu; Guisheng Deng; Ding Li

doi:10.1021/ol801571n

Oct-2-en-4-ynoyl-CoA as a specific inhibitor of Acyl-CoA oxidase

Jia Zeng, Long Wu, Xiaojian Zhang, Yuandong Liu, Guisheng Deng, Ding Li

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

10 Citations (Scopus)

Abstract

(Chemical Equation Presented) Oct-2-en-4-ynoyl-CoA was found to be a specific inhibitor of acyl-CoA oxidase in fatty acid oxidation in peroxisomes that has no inhibitory effect on acyl-CoA dehydrogenase in mitochondria. The inhibition reaction involves a nucleophilic attack of Glu421 to the δ carbon of the inhibitor. The result indicates that acyl-CoA oxidase and acyl-CoA dehydrogenase have certain differences in active-site structure, which makes it possible to control fatty acid oxidation selectively in either mitochondria or peroxisomes with different enzyme inhibitors. © 2008 American Chemical Society.

Original language	English
Pages (from-to)	4287-4290
Journal	Organic Letters
Volume	10
Issue number	19
DOIs	https://doi.org/10.1021/ol801571n
Publication status	Published - 2008

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title = "Oct-2-en-4-ynoyl-CoA as a specific inhibitor of Acyl-CoA oxidase",

abstract = "(Chemical Equation Presented) Oct-2-en-4-ynoyl-CoA was found to be a specific inhibitor of acyl-CoA oxidase in fatty acid oxidation in peroxisomes that has no inhibitory effect on acyl-CoA dehydrogenase in mitochondria. The inhibition reaction involves a nucleophilic attack of Glu421 to the δ carbon of the inhibitor. The result indicates that acyl-CoA oxidase and acyl-CoA dehydrogenase have certain differences in active-site structure, which makes it possible to control fatty acid oxidation selectively in either mitochondria or peroxisomes with different enzyme inhibitors. {\textcopyright} 2008 American Chemical Society.",

author = "Jia Zeng and Long Wu and Xiaojian Zhang and Yuandong Liu and Guisheng Deng and Ding Li",

year = "2008",

doi = "10.1021/ol801571n",

language = "English",

volume = "10",

pages = "4287--4290",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "19",

}

TY - JOUR

T1 - Oct-2-en-4-ynoyl-CoA as a specific inhibitor of Acyl-CoA oxidase

AU - Zeng, Jia

AU - Wu, Long

AU - Zhang, Xiaojian

AU - Liu, Yuandong

AU - Deng, Guisheng

AU - Li, Ding

PY - 2008

Y1 - 2008

N2 - (Chemical Equation Presented) Oct-2-en-4-ynoyl-CoA was found to be a specific inhibitor of acyl-CoA oxidase in fatty acid oxidation in peroxisomes that has no inhibitory effect on acyl-CoA dehydrogenase in mitochondria. The inhibition reaction involves a nucleophilic attack of Glu421 to the δ carbon of the inhibitor. The result indicates that acyl-CoA oxidase and acyl-CoA dehydrogenase have certain differences in active-site structure, which makes it possible to control fatty acid oxidation selectively in either mitochondria or peroxisomes with different enzyme inhibitors. © 2008 American Chemical Society.

AB - (Chemical Equation Presented) Oct-2-en-4-ynoyl-CoA was found to be a specific inhibitor of acyl-CoA oxidase in fatty acid oxidation in peroxisomes that has no inhibitory effect on acyl-CoA dehydrogenase in mitochondria. The inhibition reaction involves a nucleophilic attack of Glu421 to the δ carbon of the inhibitor. The result indicates that acyl-CoA oxidase and acyl-CoA dehydrogenase have certain differences in active-site structure, which makes it possible to control fatty acid oxidation selectively in either mitochondria or peroxisomes with different enzyme inhibitors. © 2008 American Chemical Society.

UR - http://www.scopus.com/inward/record.url?scp=55449119779&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-55449119779&origin=recordpage

U2 - 10.1021/ol801571n

DO - 10.1021/ol801571n

M3 - RGC 21 - Publication in refereed journal

C2 - 18754593

SN - 1523-7060

VL - 10

SP - 4287

EP - 4290

JO - Organic Letters

JF - Organic Letters

IS - 19

ER -

Oct-2-en-4-ynoyl-CoA as a specific inhibitor of Acyl-CoA oxidase

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