Nuclear penetration of surface functionalized gold nanoparticles

Yan-Juan Gu; Jinping Cheng; Chun-Chi Lin; Yun Wah Lam; Shuk Han Cheng; Wing-Tak Wong

doi:10.1016/j.taap.2009.03.009

Nuclear penetration of surface functionalized gold nanoparticles

Yan-Juan Gu
, Jinping Cheng
, Chun-Chi Lin
, Yun Wah Lam
, Shuk Han Cheng
, Wing-Tak Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

199 Citations (Scopus)

Abstract

Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA) to form a self-assembled monolayer and subsequently conjugated with NH₂-PEG-NH₂ through amidation between the amine end groups on PEG and the carboxylic acid groups on the particles. The biocompatibility and intracellular fate of PEG-modified gold nanoparticles (AuNP

Original language	English
Pages (from-to)	196-204
Journal	Toxicology and Applied Pharmacology
Volume	237
Issue number	2
DOIs	https://doi.org/10.1016/j.taap.2009.03.009
Publication status	Published - 1 Jun 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Biomaterials
Gold nanoparticles
Nuclear penetration
Surface modification

Policy Impact

Cited in Policy Documents

Access Output

10.1016/j.taap.2009.03.009

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{3f11609ea6fe489ab792d9c44acf9f18,

title = "Nuclear penetration of surface functionalized gold nanoparticles",

abstract = "Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA) to form a self-assembled monolayer and subsequently conjugated with NH2-PEG-NH2 through amidation between the amine end groups on PEG and the carboxylic acid groups on the particles. The biocompatibility and intracellular fate of PEG-modified gold nanoparticles (AuNP",

keywords = "Biomaterials, Gold nanoparticles, Nuclear penetration, Surface modification",

author = "Yan-Juan Gu and Jinping Cheng and Chun-Chi Lin and Lam, \{Yun Wah\} and Cheng, \{Shuk Han\} and Wing-Tak Wong",

year = "2009",

month = jun,

day = "1",

doi = "10.1016/j.taap.2009.03.009",

language = "English",

volume = "237",

pages = "196--204",

journal = "Toxicology and Applied Pharmacology",

issn = "0041-008X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Nuclear penetration of surface functionalized gold nanoparticles

AU - Gu, Yan-Juan

AU - Cheng, Jinping

AU - Lin, Chun-Chi

AU - Lam, Yun Wah

AU - Cheng, Shuk Han

AU - Wong, Wing-Tak

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA) to form a self-assembled monolayer and subsequently conjugated with NH2-PEG-NH2 through amidation between the amine end groups on PEG and the carboxylic acid groups on the particles. The biocompatibility and intracellular fate of PEG-modified gold nanoparticles (AuNP

AB - Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA) to form a self-assembled monolayer and subsequently conjugated with NH2-PEG-NH2 through amidation between the amine end groups on PEG and the carboxylic acid groups on the particles. The biocompatibility and intracellular fate of PEG-modified gold nanoparticles (AuNP

KW - Biomaterials

KW - Gold nanoparticles

KW - Nuclear penetration

KW - Surface modification

UR - https://www.scopus.com/pages/publications/67349146754

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-67349146754&origin=recordpage

UR - https://app-overton-io.ezproxy.cityu.edu.hk/articles.php?query=10.1016/j.taap.2009.03.009

U2 - 10.1016/j.taap.2009.03.009

DO - 10.1016/j.taap.2009.03.009

M3 - RGC 21 - Publication in refereed journal

C2 - 19328820

SN - 0041-008X

VL - 237

SP - 196

EP - 204

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

IS - 2

ER -

Nuclear penetration of surface functionalized gold nanoparticles

Abstract

UN SDGs

Research Keywords

Policy Impact

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this