Nuclear penetration of surface functionalized gold nanoparticles

Yan-Juan Gu; Jinping Cheng; Chun-Chi Lin; Yun Wah Lam; Shuk Han Cheng; Wing-Tak Wong

doi:10.1016/j.taap.2009.03.009

Author(s)

Yan-Juan Gu
Jinping Cheng
Chun-Chi Lin
Yun Wah Lam
Wing-Tak Wong

Detail(s)

Original language	English
Pages (from-to)	196-204
Journal / Publication	Toxicology and Applied Pharmacology
Volume	237
Issue number	2
Publication status	Published - 1 Jun 2009

Link(s)

DOI	DOI https://doi.org/10.1016/j.taap.2009.03.009 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-67349146754&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(3f11609e-a6fe-489a-b792-d9c44acf9f18).html

Abstract

Free gold nanoparticles easily aggregate when the environment conditions change. Here, gold nanoparticles (AuNPs) with average diameter of 3.7 nm were prepared and then modified with poly(ethylene glycol) (PEG) to improve stability. The gold nanoparticles were first surface-modified with 3-mercaptopropionic acid (MPA) to form a self-assembled monolayer and subsequently conjugated with NH₂-PEG-NH₂ through amidation between the amine end groups on PEG and the carboxylic acid groups on the particles. The biocompatibility and intracellular fate of PEG-modified gold nanoparticles (AuNP

Research Area(s)

Biomaterials, Gold nanoparticles, Nuclear penetration, Surface modification

SDG 3 - Good Health and Well-being

Citation Format(s)

[ RIS ] [ BibTeX ]

Nuclear penetration of surface functionalized gold nanoparticles. / Gu, Yan-Juan; Cheng, Jinping; Lin, Chun-Chi et al.
In: Toxicology and Applied Pharmacology, Vol. 237, No. 2, 01.06.2009, p. 196-204.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Gu, Y-J, Cheng, J, Lin, C-C, Lam, YW, Cheng, SH & Wong, W-T 2009, 'Nuclear penetration of surface functionalized gold nanoparticles', Toxicology and Applied Pharmacology, vol. 237, no. 2, pp. 196-204. https://doi.org/10.1016/j.taap.2009.03.009

Gu, Y.-J., Cheng, J., Lin, C.-C., Lam, Y. W., Cheng, S. H., & Wong, W.-T. (2009). Nuclear penetration of surface functionalized gold nanoparticles. Toxicology and Applied Pharmacology, 237(2), 196-204. https://doi.org/10.1016/j.taap.2009.03.009

Gu YJ, Cheng J, Lin CC, Lam YW, Cheng SH, Wong WT. Nuclear penetration of surface functionalized gold nanoparticles. Toxicology and Applied Pharmacology. 2009 Jun 1;237(2):196-204. doi: 10.1016/j.taap.2009.03.009

Gu, Yan-Juan ; Cheng, Jinping ; Lin, Chun-Chi et al. / Nuclear penetration of surface functionalized gold nanoparticles. In: Toxicology and Applied Pharmacology. 2009 ; Vol. 237, No. 2. pp. 196-204.