Novel phthalocyanine and PEG-methacrylates based temperature-responsive polymers for targeted photodynamic therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Wei Zhang
  • Jun Li
  • Weidong Zhang
  • Zhijun Hu
  • Xiong-Jie Jiang
  • To Ngai
  • Gaojian Chen

Detail(s)

Original languageEnglish
Pages (from-to)782-788
Journal / PublicationPolymer Chemistry
Volume4
Issue number3
Publication statusPublished - 7 Feb 2013
Externally publishedYes

Abstract

A novel multi-targeting nanocarrier (SiPc-polymer) for photodynamic therapy (PDT) has been successfully polymerized via the incorporation of silicon(iv) phthalocyanine dichloride (SiPcCl2) to the thermoresponsive PEG-methacrylates based polymers. The resulting SiPc-polymer was characterized by 1H NMR spectroscopy, GPC, UV-Vis and elemental analysis. The lower critical solution temperature (LCST) of the SiPc-polymer can be easily controlled via changing the ratio of the applied monomers, di(ethylene glycol) methyl ether methacrylate (DEGMEMA), oligo(ethylene glycol) methyl ether methacrylate (OEGMEMA, Mw = 475 g mol-1) and 2-hydroxyethyl methacrylate (HEMA). The synthesized polymers assemble into nanoparticles (70 nm) in aqueous solution, which normally exhibits permeation and retention (EPR) effects, the thermo-responsive features provide the possibility to selectively accumulate at a maligned tissue site upon mild heating and high singlet oxygen quantum yields (ΦΔ = 0.55) are obtained which guarantee the controlled liberation of reactive oxygen species upon light irradiation. This provides a simple way to synthesize a multi-targeting drug carrier system for PDT. © 2013 The Royal Society of Chemistry.

Citation Format(s)

Novel phthalocyanine and PEG-methacrylates based temperature-responsive polymers for targeted photodynamic therapy. / Zhang, Wei; Li, Jun; Zhang, Weidong; Hu, Zhijun; Jiang, Xiong-Jie; Ngai, To; Lo, Pui-Chi; Chen, Gaojian.

In: Polymer Chemistry, Vol. 4, No. 3, 07.02.2013, p. 782-788.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review