Novel Gelatin-based Nano-gels with Coordination-induced Drug Loading for Intracellular Delivery

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

12 Scopus Citations
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Original languageEnglish
Pages (from-to)840-844
Journal / PublicationJournal of Materials Science and Technology
Issue number9
Online published13 Apr 2016
Publication statusPublished - Sept 2016
Externally publishedYes


In this study, we develop the gelatin-dopamine (Gel-Dopa) nano-gels (GDNGs) and explore their potential as drug delivery vehicles. The Gel-Dopa precursor is synthesized using EDC/NHS coupling reaction, in which the catechols can coordinate with transition metal ions such as Fe 3+ . These novel GDNGs exhibit excellent cytocompatibility. The model drug, doxorubicin (Dox), is readily conjugated into catechol of GDNGs by the coordination cross-link of Fe 3+ ion. The morphology and size distribution of the nano-gels are characterized via field emission scanning electron microscopy and particle size analyzer, respectively. The GDNGs loaded with Dox (GDNGs-Dox) is capable of efficiently penetrating cell membrane and enter the HeLa cells. The endocytosed GDNGs-Dox release Dox molecules and subsequently kill the tumor cells.  © 2016

Research Area(s)

  • Coordination interaction, Dopamine, Doxorubicin, Drug delivery, Gelatin