Novel Gelatin-based Nano-gels with Coordination-induced Drug Loading for Intracellular Delivery
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 840-844 |
| Journal / Publication | Journal of Materials Science and Technology |
| Volume | 32 |
| Issue number | 9 |
| Online published | 13 Apr 2016 |
| Publication status | Published - Sept 2016 |
| Externally published | Yes |
Link(s)
Abstract
In this study, we develop the gelatin-dopamine (Gel-Dopa) nano-gels (GDNGs) and explore their potential as drug delivery vehicles. The Gel-Dopa precursor is synthesized using EDC/NHS coupling reaction, in which the catechols can coordinate with transition metal ions such as Fe 3+ . These novel GDNGs exhibit excellent cytocompatibility. The model drug, doxorubicin (Dox), is readily conjugated into catechol of GDNGs by the coordination cross-link of Fe 3+ ion. The morphology and size distribution of the nano-gels are characterized via field emission scanning electron microscopy and particle size analyzer, respectively. The GDNGs loaded with Dox (GDNGs-Dox) is capable of efficiently penetrating cell membrane and enter the HeLa cells. The endocytosed GDNGs-Dox release Dox molecules and subsequently kill the tumor cells. © 2016
Research Area(s)
- Coordination interaction, Dopamine, Doxorubicin, Drug delivery, Gelatin
Citation Format(s)
Novel Gelatin-based Nano-gels with Coordination-induced Drug Loading for Intracellular Delivery. / Fan, Changjiang; Wang, Dong-An.
In: Journal of Materials Science and Technology, Vol. 32, No. 9, 09.2016, p. 840-844.
In: Journal of Materials Science and Technology, Vol. 32, No. 9, 09.2016, p. 840-844.
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
