Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "inverse Drug Discovery"

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Overview

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Chemistry

Drug Discovery Chemistry

Cyclopropenone Chemistry

Chemical Reaction Chemistry

Electrophile Chemistry

Glutathione Chemistry

Structure Chemistry

Reactivity Chemistry

Chemistry Chemistry

Optimization Chemistry

Cycloaddition Chemistry

Inhibitor Chemistry

Signal Transduction Chemistry

Keyphrases

Living Cells Keyphrases

Drug Discovery Keyphrases

Triple-negative Bre... Keyphrases

Electrophilic Warhe... Keyphrases

Cancer Drivers Keyphrases

Cyclopropenone Keyphrases

Electrophile Keyphrases

Glutathione S-trans... Keyphrases

Cycloaddition React... Keyphrases

Potent Inhibitor Keyphrases

Proteome Keyphrases

Signaling Pathway Keyphrases

Structure Optimizat... Keyphrases

Bioorthogonal React... Keyphrases

Photo-triggered Keyphrases

Medicinal Chemistry Keyphrases

Cellular Targets Keyphrases

Catalytic Active Si... Keyphrases

Drug pipeline Keyphrases

Warhead Keyphrases

Triarylphosphine Keyphrases

INIS

transferases INIS

glutathione INIS

reactivity INIS

optimization INIS

validation INIS

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